Volume 51, Issue 1

2017 · pp. 1–161 · 20 articles

Volume: 51
Issue: 1
Published: 2017
Pages: 1–161
Articles: 20
Sections: 2
ISSN: Online - 0019-5464
Journal: IJPER

Review Article Original Article

In this issue

Review Article

Review
Factor VIIa and Factor IXa Inhibitors as Anticoagulants: A Review
Kumbhar Santosh Sahadeo, Choudhari Prafulla Balkrishna, Pawar Vasanti Suresh, Bhatia Neela Manish, Bhatia Manish Sudesh
pp. 1–8 · DOI: 10.5530/ijper.51.1.1 · Published 2017
Introduction: Anticoagulants are used as preventive agents in deep vein thrombosis to prevent blood clots, venous and arterial thromboembolism, but the current therapy of anticoagulants have several limitations like pati…

Original Article

Article
Using Vincent van Gogh’s Illnesses to Revise Medicinal Chemistry
Yicheng Mei, Baowei Yang
pp. 9–13 · DOI: 10.5530/ijper.51.1.2 · Published 2017
Objective: Review sessions provide an opportunity for the students to revise materials they have learned previously. A case study has been designed using the story of Vincent van Gogh, a legendary painter with various il…
Article
Effect of integrating research skills with basic sciences in an interdisciplinary integrated endocrine module on students’ satisfaction and performance
ZeinabAlrefaie ZeinabAlrefaie, BasemEldeek BasemEldeek, NasraAyuob NasraAyuob
pp. 14–19 · DOI: 10.5530/ijper.51.1.3 · Published 2017
Background: A system-based integrated curriculum has been implemented at Faculty of Medicine, King Abdulaziz University since the academic year 2006/2007. There were many calls to increase the integration level and to in…
Article
Diversity of Pharmacy Faculty Members between UK and US
Weixiang Zhang, Yitao Wang, Defang Ouyang
pp. 20–24 · DOI: 10.5530/ijper.51.1.4 · Published 2017
Objective: The aim of the research was to characterize the diversity of current pharmacy faculty members in the US and UK. Methods: An online self-completion survey was designed and sent to the faculty members from the t…
Article
Identification of Potential Inhibitors against the Human Influenza A Virus Targeting the CPSF30 and RNA Binding Domains of the NS1 Protein: An E-Pharmacophore approach.
Ishwar Chandra, Abhisek Kumar Behera, Sarah Sabu Cherian
pp. 25–33 · DOI: 10.5530/ijper.51.1.5 · Published 2017
Background: Common occurrences of influenza virus strains resistant to known neuraminidase and matrix protein inhibitors like oseltamivir and amantadine respectively necessitate the development of newer antivirals. The v…
Article
DUSR (Distributed Ultrafast Shape Recognition): a Hadoop Based Tool to Identify Similar Shaped Ligand Molecules
Vandana Kumari, Rashmi Tripathi, Sunil Patel, Utkarsh Raj, Pritish Kumar Varadwaj
pp. 34–42 · DOI: 10.5530/ijper.51.1.6 · Published 2017
Background: Identifying potential drug candidates through Ligand-based virtual screening is often associated with processing of huge amount of data and hence is a computational intensive task. Ultrafast Shape Recognition…
Article
Morus rubra Extract Induces G1 Cell Cycle Arrest and Apoptosis in Human Lung and Prostate Cancer Cells
Ibrahim Turan, Selim Demir, Kagan Kilinc, Yuksel Aliyazicioglu, Ahmet Alver, Sema Misir, Serap Ozer Yaman, Kubra Akbulut, Ahmet Mentese, Orhan Deger
pp. 51–58 · DOI: 10.5530/ijper.51.1.8 · Published 2017
Objective: Cancer is one of the most deadly types of disease and evasion from apoptosis and unstoppable cell proliferation are accepted as its distinctive features. Many studies have evaluated the cytotoxic effect of dif…
Article
Protective Effect of Heat-Treated Cucumber (Cucumis sativus L.) Juice Against Lead-Induced Detoxification in Rat Model
Vivek Kumar Bajpai, Ji-Eun Kim, Sun Chul Kang
pp. 59–69 · DOI: 10.5530/ijper.51.1.9 · Published 2017
Background: In recent years, the development of efficient green chemistry approaches for detoxification of heavy metal such as lead (Pb) poisoning has become a major focus of researchers. Objectives: This study was aimed…
Article
Pharmacognostic Evaluation of DPSUU III IN Breast Tumor Growth By G0/G1 Cell Cycle Arrest
Debasish Pradhan, Toffa Dasmohapatra, Gitanjali Tripathy
pp. 70–76 · DOI: 10.5530/ijper.51.1.10 · Published 2017
Objective: Plant-inferred bioactive particles have been utilized to turn away or treat tumor for a considerable length of time. As of late plant blends were found to have significantly more grounded exercises than utiliz…
Article
Effect of Pravastatin on Levels of Filtration Slit Diaphragm Protein and Oxidative Stress in Doxorubicin- Induced Nephrotoxicity
Wesam Kooti, Esrafil Mansouri, Mohammad-Ali Assarehzadegan³, Fereshteh Nejad–Dehbashi⁴
pp. 77–82 · DOI: 10.5530/ijper.51.1.11 · Published 2017
Introduction: Nephrotoxicity is one of the complications the use of doxorubicin (DXR) which may be caused by the formation of free radicals. The aim of this study was to investigate the effects of pravastatin (PS) on dox…
Article
Role of Brain Angiotensin (1-7) In Chronic Hyperglycaemia Induced Nephropathy in Wistar Rats
Richa Shakya, Ahsas Goyal, Bhupesh Chandra Semwal, Niraj Kumar Singh, Harlokesh Narayan Yadav
pp. 83–91 · DOI: 10.5530/ijper.51.1.12 · Published 2017
Objective: Ang (1-7) recognised as a biologically active component of renin angiotensin system (RAS). It has been documented that peripheral activity of Ang (1-7) gets reduced during diabetic nephropathy (DN) which is on…
Article
Characterization of Peripheral Neuropathy in Rat Model of Type 2 Diabetes
Bina Kumari Mehta, Damini Nerkar, Sugato Banerjee
pp. 92–101 · DOI: 10.5530/ijper.51.1.13 · Published 2017
Diabetic neuropathy, a microvascular complication associated with diabetes, is one of the most common forms of neuropathy. Current rodent models of type 2 diabetes are mostly transgenic which fail to mimic human type 2 d…
Article
Synthesis and Spectroscopic Characterization of Metal Complexes of Rosuvastatin
Arman Tabassum, Muhammad Saeed Arayne, Najma Sultana
pp. 102–109 · DOI: 10.5530/ijper.51.1.14 · Published 2017
Context: Rosuvastatin is a cholesterol lowering drug. It belongs to class statin. It is prescribed to the patients of coronary artery disease; atherosclerosis; thrombosis; increased low-density-lipoprotein; lipid and tri…
Article
Molecular Docking studies and in-silico ADMET Screening of Some novel Oxazine substituted 9-Anilinoacridines as Topoisomerase II Inhibitors
Rajagopal Kalirajan, Sundaram Sankar, Selvaraj Jubie, Byran Gowramma
pp. 110–115 · DOI: 10.5530/ijper.51.1.15 · Published 2017
Introduction: In general, 9-aminoacridine derivatives are inhibiting DNA topoisomerase II (topoII) because of their strong activity due to the ability of acridine nucleus to intercalate into DNA base pair. To get insight…
Article
Development and Evaluation of Diclofenac sodium Controlled Release Dosage Forms Using Natural, Hydrophilic and Hydrophobic Polymers and its Comparative Studies
Divvela Hema Naga Durga, Duppala Lohithasu, Kolapalli Venkata Ramana Murthy
pp. 116–127 · DOI: 10.5530/ijper.51.1.16 · Published 2017
The aim of the present study is to develop the controlled release dosage form of diclofenac using hydrophilic polymers (xanthan gum from natural origin, hydroxy propyl methyl cellulose K 100M from semisynthetic origin) a…
Article
Design of Experiments for Coating Process of Valsartan and Pravastatin Fixed-dose Combination Tablet
Kangmin Kim, Jae Seon Kang
pp. 128–135 · DOI: 10.5530/ijper.51.1.17 · Published 2017
Aim of work: The purpose of this study was to prepare the ranges of critical process parameters (CPP) (spray rate, pan speed, and inlet temperature) in the coating process of valsartan and pravastatin fixed-dose combinat…
Article
Prevalence and Risk Factors of Anxiety among Female Governmental Secondary Schools Students in Al-madinah, Saudi Arabia
Awad Mohammed Al-Qahtani, Mashael B. Al-Harbi
pp. 136–143 · DOI: 10.5530/ijper.51.1.18 · Published 2017
Aim: The study aimed to measure the prevalence and risk factors of Anxiety among Female Governmental Secondary schools students, in Al-Madinah, Saudi Arabia. Methods: Cross sectional study was conducted in Al-Madinah cit…
Article
Antibiotic De-escalation Therapy in Neurosurgical Patients with Ventilator-Associated Pneumonia in Intensive Care Unit: A Retrospective Observational Study
Rahela Ambaras Khan, Zoriah Aziz
pp. 144–149 · DOI: 10.5530/ijper.51.1.19 · Published 2017
Context: Antibiotic de-escalation practice is gaining interest in the intensive care units (ICU). However, there is limited evidence to support this approach in neurosurgical patients with Ventilator-Associated Pneumonia…
Article
Vildagliptin and Insulin Combinatorial Therapy Drug Safety Monitoring in Diabetic Rats
Priya Ebenesan, Mallika Jainu
pp. 150–155 · DOI: 10.5530/ijper.51.1.20 · Published 2017
Background: Type 2 Diabetes Mellitus is a long term metabolic disorder that is characterized by high blood sugar, insulin resistance, and lack of insulin. Based on the understanding of the pathogenesis of T2DM, several d…
Article
Utilization Pattern of Non-steroidal Anti-inflammatory Drugs at a Primary Health Care in Malaysia
Khairani Azian Khairudin, Abubakar Ibrahim Jatau, Mohamed Mansor Manan, Chua Say Tiong, Mallikarjun Chitneni, Amir Heberd Abdullah, Sundara Rajan Mahalingam, Kamaruddin Arshad
pp. 156–161 · DOI: 10.5530/ijper.51.1.21 · Published 2017
Introduction: Non-steroidal anti-inflammatory drugs (NSAIDs) are among medications most commonly prescribed and used world wide mainly in the developed countries. Variation in terms of drug utilization pattern and advers…