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International Journal of Pharmaceutical InvestigationNOW IN
Article

A novel herbal formulation in the management of diabetes

Santosh S Bhujbal1★, Sunita S Hadawale1, Parag A Kulkarni1, Jayant S Bidkar2, Vidya A Thatte1, Clarine A Providencia1, Rupesh R Yeola1★ Corresponding author

  1. 1Padmashree Dr. D.Y.Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, INDIA.
  2. 2Sharadchandra Pawar College of Pharmacy, Dumberwadi (Otur), Junner, Pune, INDIA.

CORRESPONDENCE

Santosh S Bhujbal

Padmashree Dr. D.Y.Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, INDIA.

santoshbhujbals@yahoo.com

Volume 1, Issue 4 · pp. 222–226 · PUBLISHED · DOI: 10.4103/2230-973X.93009

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ABSTRACT

Background and Aim:Momordica charantia Linn. is traditionally used as a medicine for diabetes. The present investigation was aimed to formulate and evaluate transdermal patchesof Momordica charantia Linn. Materials and Methods: The transdermal films containing the herbal drug component fractionated fromethanolicextract of M. charantia fruits were prepared by using hydroxy propyl methyl cellulose as a polymer.The films were evaluated for folding endurance, thickness, weight variation, drug contents and in vitro diffusion studies and in vivo parameterslike acute and sub-acute antihyperglycemic activity in diabetic rats, biochemicalstudies, skin irritation in rats and stability studies. Result anddiscussion:The weightof transdermal patches of M. charantia (2 cm2; 10 mg/patch) and was found to be 0.03 gm.Thickness of patches of M. charantia (2 cm2; 10 mg/patch) was found to be satisfactory. The percentage release of active constituents from transdermal patches of M.charantia (2 cm2; 10 mg/patch) was found to be 47.59% in 10% hydroalcoholic phosphate buffer pH 7.4 at the end of 6 h. The transdermal route exhibited negligible skin irritation and in vivo results revealed that the patches successfully decrease the blood glucose level. Conclusion: From the results, we concluded that the well-known herbal drug M. charantia Linn. have been found to be effective for diabetes through modern pharmaceutical formulation techniques.

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    Bhujbal, S. S., Hadawale, S. S., Kulkarni, P. A., Bidkar, J. S., Thatte, V. A., Providencia, C. A., & Yeola, R. R. (). A novel herbal formulation in the management of diabetes. International Journal of Pharmaceutical Investigation, 1(4), 222–226. https://doi.org/10.4103/2230-973X.93009