Volume 6, Issue 2

Original Research Article

1. Article

   Formulation, characterization and evaluation of the effect of polymer concentration on the release behavior of insulin-loaded Eudragit®-entrapped mucoadhesive microspheres

   Franklin C. Kenechukwu, Mumuni A. Momoh

   pp. 69–77 · DOI: 10.4103/2230-973X.177806

   Introduction:The aim of this study was to use Eudragit® RL 100 (pH-independent polymer) and magnesium stearate (a hydrophobic droplet stabilizer) in combination to improve the controlled release effect of insulin-loaded …

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2. Article

   Self-assembled supramolecular hydrogel based on PCL-PEG-PCL triblock copolymer and γ-cyclodextrin inclusion complex for sustained delivery of dexamethasone

   Elham Khodaverdi, Marzieh Gharechahi, Mona Alibolandi, Farnaz Sadat Mirzazadeh Tekie, Bibi Zahra Khashyarmanesh, Farzin Hadizadeh

   pp. 78–85 · DOI: 10.4103/2230-973X.177809

   In this study, thermosensitive, water-soluble, and biodegradable triblock copolymer PCL600-PEG6000-PCL600 was used to form supramolecular hydrogel (SMGel) by inclusion complexation with γ-cyclodextrin (γ-CD). The prepare…

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3. Article

   Preparation and characterization of gatifloxacin-loaded sodium alginate hydrogel membranes supplemented with hydroxypropyl methylcellulose and hydroxypropyl cellulose polymers for wound dressing

   Durai Prabu, Amin F. Majdalawieh, Imad A. Abu-Yousef, Kadambari Inbasekaran, Tharani Balasubramaniam, Narayanan Nallaperumal, Conjeevaram J. Gunasekar

   pp. 86–95 · DOI: 10.4103/2230-973X.177810

   Introduction: The aim of this study is to evaluate gatifloxacin-loaded sodium alginate hydrogel membranes, supplemented with glycerol (a plasticizer), glutaraldehyde (a cross-linking agent), and hydroxypropyl methylcellu…

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4. Article

   Chondroitin sulfate-chitosan nanoparticles for ocular delivery of bromfenac sodium: Improved permeation, retention, and penetration

   Tara Abdulrahman Abdullah, Naz Jamal Ibrahim, Musarrat Husain Warsi

   pp. 96–105 · DOI: 10.4103/2230-973X.177823

   Introduction:Superiority of topical instillation of drug into the cul-de-sac for the treatment of various ophthalmic complications can be validated with commercial availability of a large number of conventional formulati…

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5. Article

   Localization of fluconazole in oral cavity by preferential coating of buccoadhesive tablet for treatment of oral thrush

   Kamla Pathak, Vijay Sharma, Nida Akhtar, Pragya Rastogi

   pp. 106–115 · DOI: 10.4103/2230-973X.177826

   Background:The present research work was aimed at localization of fluconazole in the oral cavity by preferential coating of buccoadhesive tablet for the treatment of oral thrush.Materials and Methods: In order to achieve…

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6. Article

   Formulation and evaluation of atenolol floating bioadhesive system using optimized polymer blends

   Haritha Siddam, Niranjan G. Kotla, Balaji Maddiboyina, Sima Singh, Omprakash Sunnapu, Anil Kumar, Dinesh Sharma

   pp. 116–122 · DOI: 10.4103/2230-973X.177832

   Introduction:Oral sustained release gastro retentive dosage forms offer several advantages for drugs having absorption from the upper gastrointestinal tract to improve the bioavailability of medications which have narrow…

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7. Article

   Prolonged drug delivery system of an antifungal drug by association with polyamidoamine dendrimers

   Jobin Jose, R Narayana Charyulu

   pp. 123–127 · DOI: 10.4103/2230-973X.177833

   Introduction: The potent antifungal agent amphotericin B (AmB) is not freely soluble in water. The clinical use of AmB is limited by nephrotoxicity and poor water solubility. Polyamidoamine (PAMAM) dendrimer offers an id…

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