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International Journal of Pharmaceutical InvestigationNOW IN
Article

Formulation, characterization and evaluation of the effect of polymer concentration on the release behavior of insulin-loaded Eudragit®-entrapped mucoadhesive microspheres

Franklin C. Kenechukwu1★, Mumuni A. Momoh1★ Corresponding author

  1. 1Drug Delivery and Nanomedicines Research Unit, Department of Pharmaceutics, University of Nigeria, Nsukka, Enugu State, NIGERIA.

CORRESPONDENCE

Franklin C. Kenechukwu

Drug Delivery and Nanomedicines Research Unit, Department of Pharmaceutics, University of Nigeria, Nsukka, Enugu State, NIGERIA.

frankline.kenechukwu@unn.edu.ng

Volume 6, Issue 2 · pp. 69–77 · PUBLISHED · DOI: 10.4103/2230-973X.177806

View on IJPI original site ↗

ABSTRACT

Introduction:The aim of this study was to use Eudragit® RL 100 (pH-independent polymer) and magnesium stearate (a hydrophobic droplet stabilizer) in combination to improve the controlled release effect of insulin-loaded Eudragit® entrapped microspheres prepared by the emulsification-coacervation technique. Materials and Methods:Mucoadhesive insulin-loaded microspheres containing magnesium stearate and varying proportions of Eudragit® RL 100 were prepared by the emulsification-coacervation technique and evaluated for thermal properties, physicochemical performance, and in vitro dissolution in acidic and subsequently basic media.Results:Stable, spherical, brownish, discrete, free flowing and mucoadhesive insulin-loaded microspheres with size range of 14.20 ± 0.30-19.80 ± 0.60 µm and loading efficiency of 74.55 ± 1.05-75.90 ± 1.94% were formed. After 3 h, microspheres prepared with insulin: Eudragit® RL 100 ratios of 1:4, 1:6, and 1:8 released 73.40 ± 1.38, 66.20 ± 1.59, and 71.30 ± 1.27 (%) of insulin, respectively.Conclusion:The physicochemical and physico-technical properties of the microspheres developed in this study demonstrated the effectiveness of the Eudragit® RL entrapped mucoadhesive microspheres (prepared by the emulsification-coacervation technique using varying polymer concentration) as a carrier system for oral insulin delivery.

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    Kenechukwu, F. C., & Momoh, M. A. (). Formulation, characterization and evaluation of the effect of polymer concentration on the release behavior of insulin-loaded Eudragit®-entrapped mucoadhesive microspheres. International Journal of Pharmaceutical Investigation, 6(2), 69–77. https://doi.org/10.4103/2230-973X.177806