Volume 6, Issue 2

Original Research Article

1. Article

   Formulation, characterization and evaluation of the effect of polymer concentration on the release behavior of insulin-loaded Eudragit®-entrapped mucoadhesive microspheres

   Franklin C. Kenechukwu, Mumuni A. Momoh

   pp. 69–77 · DOI: 10.4103/2230-973X.177806 · Published

   Introduction:The aim of this study was to use Eudragit® RL 100 (pH-independent polymer) and magnesium stearate (a hydrophobic droplet stabilizer) in combination to improve the controlled release effect of insulin-loaded …

2. Article

   Self-assembled supramolecular hydrogel based on PCL-PEG-PCL triblock copolymer and γ-cyclodextrin inclusion complex for sustained delivery of dexamethasone

   Elham Khodaverdi, Marzieh Gharechahi, Mona Alibolandi, Farnaz Sadat Mirzazadeh Tekie, Bibi Zahra Khashyarmanesh, Farzin Hadizadeh

   pp. 78–85 · DOI: 10.4103/2230-973X.177809 · Published

   In this study, thermosensitive, water-soluble, and biodegradable triblock copolymer PCL600-PEG6000-PCL600 was used to form supramolecular hydrogel (SMGel) by inclusion complexation with γ-cyclodextrin (γ-CD). The prepare…

3. Article

   Preparation and characterization of gatifloxacin-loaded sodium alginate hydrogel membranes supplemented with hydroxypropyl methylcellulose and hydroxypropyl cellulose polymers for wound dressing

   Durai Prabu, Amin F. Majdalawieh, Imad A. Abu-Yousef, Kadambari Inbasekaran, Tharani Balasubramaniam, Narayanan Nallaperumal, Conjeevaram J. Gunasekar

   pp. 86–95 · DOI: 10.4103/2230-973X.177810 · Published

   Introduction: The aim of this study is to evaluate gatifloxacin-loaded sodium alginate hydrogel membranes, supplemented with glycerol (a plasticizer), glutaraldehyde (a cross-linking agent), and hydroxypropyl methylcellu…

4. Article

   Chondroitin sulfate-chitosan nanoparticles for ocular delivery of bromfenac sodium: Improved permeation, retention, and penetration

   Tara Abdulrahman Abdullah, Naz Jamal Ibrahim, Musarrat Husain Warsi

   pp. 96–105 · DOI: 10.4103/2230-973X.177823 · Published

   Introduction:Superiority of topical instillation of drug into the cul-de-sac for the treatment of various ophthalmic complications can be validated with commercial availability of a large number of conventional formulati…

5. Article

   Localization of fluconazole in oral cavity by preferential coating of buccoadhesive tablet for treatment of oral thrush

   Kamla Pathak, Vijay Sharma, Nida Akhtar, Pragya Rastogi

   pp. 106–115 · DOI: 10.4103/2230-973X.177826 · Published

   Background:The present research work was aimed at localization of fluconazole in the oral cavity by preferential coating of buccoadhesive tablet for the treatment of oral thrush.Materials and Methods: In order to achieve…

6. Article

   Formulation and evaluation of atenolol floating bioadhesive system using optimized polymer blends

   Haritha Siddam, Niranjan G. Kotla, Balaji Maddiboyina, Sima Singh, Omprakash Sunnapu, Anil Kumar, Dinesh Sharma

   pp. 116–122 · DOI: 10.4103/2230-973X.177832 · Published

   Introduction:Oral sustained release gastro retentive dosage forms offer several advantages for drugs having absorption from the upper gastrointestinal tract to improve the bioavailability of medications which have narrow…

7. Article

   Prolonged drug delivery system of an antifungal drug by association with polyamidoamine dendrimers

   Jobin Jose, R Narayana Charyulu

   pp. 123–127 · DOI: 10.4103/2230-973X.177833 · Published

   Introduction: The potent antifungal agent amphotericin B (AmB) is not freely soluble in water. The clinical use of AmB is limited by nephrotoxicity and poor water solubility. Polyamidoamine (PAMAM) dendrimer offers an id…