Volume 6, Issue 3

· pp. 129–179 · 5 articles

In this issue

Review
Pharmaceutical product development: A quality by design approach
Kannissery Pramod, M. Abu Tahir, Naseem A. Charoo, Shahid H. Ansari, Javed Ali
pp. 129–138 · DOI: 10.4103/2230-973X.187350 · Published
The application of quality by design (QbD) in pharmaceutical product development is now a thrust area for the regulatory authorities and the pharmaceutical industry. International Conference on Harmonization and United S…

Article
Improved dissolution and anti-inflammatory activity of ibuprofen-polyethylene glycol 8000 solid dispersion systems
Kenneth C. Ofokansi, Franklin C. Kenechukwu, Richard O. Ezugwu, Anthony A. Attama
pp. 139–147 · DOI: 10.4103/2230-973X.187344 · Published
Background: The purpose of this study was to develop ibuprofen (IB)-polyethylene glycol (PEG) 8000 solid dispersions (SDs) and investigate them for in vitro dissolution and in vivo anti-inflammatory activity. Materials a…

Article
Preparation and evaluation of a novel oral delivery system for low molecular weight heparin
Nallaguntla Lavanya, Yallamalli Indira Muzib, Jithan Aukunuru, Umamahesh Balekari
pp. 148–157 · DOI: 10.4103/2230-973X.187351 · Published
Objective: The objective of the present work was to prepare and evaluate a novel oral formulation for systemic delivery of low molecular weight heparin (LMWH). The formulation consisted of Eudragit S 100-coated positivel…
Article
Development and characterization of novel hydrogel containing antimicrobial drug for treatment of burns
Vaishali Thakkar, Vaishali Korat, Lalji Baldaniya, Mukesh Gohel, Tejal Gandhi, Nirav Patel
pp. 158–168 · DOI: 10.4103/2230-973X.187343 · Published
Introduction:The aim of burn management and therapy is fast healing and epithelisation to prevent infection. The present study is concerned with the development and characterization of a novel nanaoparticulate system; cu…
Article
Preparation, characterization, and in vivo evaluation of valsartan porous matrices using emulsion solvent evaporation technique
Govada Kishore Babu, Puttagunta Srinivasa Babu, Mukkanti Khagga
pp. 169–179 · DOI: 10.4103/2230-973X.187345 · Published
Introduction: Valsartan is a type II Biopharmaceutics Classification System (BCS) classified drug. The poor aqueous solubility restricts its use in developing sustained or controlled release systems for the treatment of …