Resveratrol attenuates malathion‑induced renal damage by declining oxidative stress in rats
Cyrus Jalili1, Shiva Roshankhah2, Yones Moradi2, Mohammad Reza Salahshoor2★★ Corresponding author
- 1Medical Biology Research Center, Kermanshah University of Medical Sciences.
- 2Department of Anatomical Sciences, Medical School, Kermanshah University of Medical Sciences, Kermanshah, IRAN.
CORRESPONDENCE
Mohammad Reza Salahshoor
Department of Anatomical Sciences, Medical School, Kermanshah University of Medical Sciences, Kermanshah, IRAN.
Volume 8, Issue 4 · pp. 192–199 · PUBLISHED · DOI: 10.4103/jphi.JPHI_7_19
ABSTRACT
Background:Malathion is the most organophosphates which are capable to produce free radicals and induce disturbance in body antioxidant. Resveratrol is an herbal polyphenol and it has been beneficial antioxidant effects during short‑term administration. This study was designed to evaluate the effects of resveratrol against damage induced by malathion to the kidneys of rats. Materials and Methods:Forty‑eight Wistar rats divided randomly into eight groups (n = 6): sham (saline) and malathion control treated groups (27 mg/kg); resveratrol groups (2, 8, and 20 mg/kg); and resveratrol + malathion‑treated groups(2, 8, and 20 mg/kg). Treatments were administered intraperitoneally and gavage daily for 45 days. Parameters related to the function and the histology of the kidneys were evaluated and statistically analyzed from kidney and blood serum samples in respect of the groups.Results: Malathion administration increased significantly Bowman’s space, qualitative histopathology indices, kidney malondialdehyde (MDA) level, blood urea nitrogen (BUN), creatinine, and nitrite oxide levels and decreased significantly total antioxidant capacity (TAC) level and diameter and number of renal corpuscles compared to the Sham group (P < 0.001). The resveratrol and resveratrol + malathion treatments in a dose‑dependent manner reduced significantly Bowman’s space, qualitative histopathology indices, kidney MDA level, BUN, creatinine, and nitrite oxide levels and increased significantly TAC level and diameter and number of renal corpuscles compared to the malathion control group (P < 0.001). Conclusion: It seems that resveratrol administration in a dose‑dependent manner improved kidney injury induced by malathion in rats.
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Jalili, C., Roshankhah, S., Moradi, Y., & Salahshoor, M. R. (). Resveratrol attenuates malathion‑induced renal damage by declining oxidative stress in rats. International Journal of Pharmaceutical Investigation, 8(4), 192–199. https://doi.org/10.4103/jphi.JPHI_7_19