Volume 3, Issue 3

Original Research Article

1. Article

   Development and evaluation of a novel biodegradable sustained release microsphere formulation of paclitaxel intended to treat breast cancer

   Jacob Shiny, Thadkapally Ramchander, Puchchakayala Goverdhan, Mohammad Habibuddin, Jithan Venkata Aukunuru

   pp. 119–125 · DOI: 10.4103/2230-973X.119212 · Published

   Objective: The objective of this study was to develop a novel 1 month depot paclitaxel (PTX) microspheres that give a sustained and complete drug release. Materials and Methods: PTX loaded microspheres were prepared by o…

2. Article

   Development and characterization of gelatin based nanoparticles for targeted delivery of zidovudine

   Namdeo R Jadhav, Ratan S Tone, Preeti V Irny, Sameer J Nadaf

   pp. 126–130 · DOI: 10.4103/2230-973X.119213 · Published

   Introduction: The present work was aimed at development and evaluation of zidovudin (AZT) loaded gelatin nanoparticles (GNPs) by simple desolvation method and further couple it with mannose. Material and Methods: Total s…

3. Article

   Synthesis characterization and in vitro drug release from acrylamide and sodium alginate based superporous hydrogel devices

   Manju Nagpal, Shailendra Kumar Singh, Dinanath Mishra

   pp. 131–140 · DOI: 10.4103/2230-973X.119215 · Published

   Objective: Present investigation was aimed at developing gastroretentive superporous hydrogels (SPHs) having desired mechanical characteristics with sustained release. Materials and Methods:The acrylamide based SPHs of v…

4. Article

   Development and optimization of enteric coated mucoadhesive microspheres of duloxetine hydrochloride using 32 full factorial design

   Anupama Setia, Sahil Kansal, Naveen Goyal

   pp. 141–150 · DOI: 10.4103/2230-973X.119217 · Published

   Background: Microspheres constitute an important part of oral drug delivery system by virtue of their small size and efficient carrier capacity. However, the success of these microspheres is limited due to their short re…

5. Article

   Design of sustained release pellets of ferrous fumarate using cow ghee as hot-melt coating agent

   Dinesh M Sakarkar, Avinash K Dorle, Nilesh Manoharrao Mahajan, Suresh Gendappa Sudke

   pp. 151–156 · DOI: 10.4103/2230-973X.119225 · Published

   Introduction: The objective of the present study was to design ferrous fumarate (FF) sustained release (SR) pellets using of cow ghee (CG) as an important hot-melt coating (HMC) agent. Materials and Methods:The pellets w…

6. Article

   Comparative evaluation of single and bilayered lamotrigine floating tablets

   PK Lakshmi, M Sridhar, B Shruthi

   pp. 157–162 · DOI: 10.4103/2230-973X.119227 · Published

   Aim: The purpose of this study was to prepare lamotrigine (LM) bilayered and single layered floating tablets and to compare their release profiles. Materials and Methods:LM floating tablets were prepared by direct compre…

7. Article

   Ethyl cellulose and hydroxypropyl methyl cellulose buoyant microspheres of metoprolol succinate: Influence of pH modifiers

   Neha S Raut, Sachin Somvanshi, Amol B Jumde, Harsha M Khandelwal, Milind J Umekar, Nandkishor Ramdas Kotagale

   pp. 163–170 · DOI: 10.4103/2230-973X.119235 · Published

   Introduction: Incorporation of pH modifier has been the usual strategy employed to enhance the dissolution of weakly basic drug from floating microspheres. Microspheres prepared using a combination of both ethyl cellulos…