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JPP · Lens · Late-Onset Clozapine-Induced Agranulocytosis in a Young Woman with Paranoid Schizophrenia

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Article · Volume 11, Issue 4 · pp. 140–141

Late-Onset Clozapine-Induced Agranulocytosis in a Young Woman with Paranoid Schizophrenia

Anuhya Vinayaka1, Shubha Sheshadri2, Sharath P. Madhyastha2, Ganesh V. Shetty2, Charan Thej Reddy2

  1. 1Department of Pharmacology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.
  2. 2Department of Medicine, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Abstract

Treatment of schizophrenia has taken so many turns, and adverse effects of the drugs still continue to remain as a hurdle in the management. Clozapine is considered to be the better promising drug in the treatment of paranoid schizophrenia with minimal side effects. Clozapine-induced agranulocytosis is one adverse event that troubles clinicians, and it requires a vigilant eye to look for the signs. In the present study, the authors discuss a case which has developed agranulocytosis in the later stages of clozapine treatment.

Keywords: Agranulocytosis; clozapine; late adverse event; paranoid; schizophrenia

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