Study of Hemodynamic Effects of Preoperative Single-Bolus Dexmedetomidine in Elective Laparoscopic Surgeries
Fathima Fasil1★, Girish Saundattikar1, Reema Hemant Jawale1, Naveen Kumar J.1★ Corresponding author
- 1Department of Anaesthesia, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pimpri, Pune, Maharashtra, India.
CORRESPONDENCE
Fathima Fasil
Department of Anaesthesia, Dr. D. Y. Patil Medical College and Research Centre, Pimpri, Pune, Maharashtra 411018, India.
Received: 20-12-2021; Revised: 04-02-2022; Accepted: 12-02-2022.
Volume 13, Issue 1 · pp. 85–91 · PUBLISHED 2022 · DOI: 10.1177/0976500X221080390
ABSTRACT
Objective: To observe the hemodynamic effects of a single bolus dose of dexmedetomidine in patients undergoing elective laparoscopic surgeries. Methods: A total of 60 adult patients were randomized into two groups of 30 each. Group D patients were given 1 µg/kg dexmedetomidine in 50 mL of saline as a single-dose infusion over 10 min before induction. Group S patients were given a 50-mL 0.9% NS slow infusion over 10 min. Groups D and S patients were premedicated 10 min prior to surgery. Baseline vital and hemodynamic parameters were monitored during the perioperative period. Conclusion: Premedicating with a single bolus of 1 µg/kg IV dexmedetomidine has been proven safe and effective in maintaining perioperative hemodynamic stability, although few developed bradycardia and hypotension, which were managed without any adverse outcome. Furthermore, dexmedetomidine effectively reduced the incidence of shivering.
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Fasil, F., Saundattikar, G., Jawale, R. H., & J., N. K. (2022). Study of Hemodynamic Effects of Preoperative Single-Bolus Dexmedetomidine in Elective Laparoscopic Surgeries. Journal of Pharmacology and Pharmacotherapeutics, 13(1), 85–91. https://doi.org/10.1177/0976500X221080390