Bullous Drug Reaction with Dipeptidyl Peptidase-4 (DPP-4) Inhibitors
K. Geetha1★, Puja Puja2★ Corresponding author
- 1Department of Dermatology, All India Institutes of Medical Sciences (AIIMS) Raebareli, Raebareli, Uttar Pradesh, India.
- 2Department of Pharmacology, All India Institutes of Medical Sciences (AIIMS) Raebareli, Raebareli, Uttar Pradesh, India.
CORRESPONDENCE
K. Geetha
Department of Dermatology, All India Institutes of Medical Sciences (AIIMS) Raebareli, Raebareli, Uttar Pradesh 229001, India.
Received: 20-12-2021; Revised: 04-02-2022; Accepted: 12-02-2022.
Volume 13, Issue 1 · pp. 99–101 · PUBLISHED 2022 · DOI: 10.1177/0976500X221080309
ABSTRACT
Hypoglycemic drugs in the dipeptidyl peptidase-4 (DPP-4) inhibitor class are used as a second-line treatment for type 2 diabetes mellitus. With DPP-4 inhibitors, there have been a few reports of cutaneous side effects such as bullous response, fixed drug eruption, and photosensitivity. There is no definitive pathophysiology for the above mentioned allergic reactions. Sitagliptin phosphate belongs to the DPP-4 inhibitor class. This is a case report of a sitagliptin-induced bullous drug reaction manifesting three weeks after starting therapy. He had bullous pemphigoid-like eruptions all over the body. The patient showed improvement once sitagliptin was discontinued alon with oral and topical steroid treatment.
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Geetha, K., & Puja, P. (2022). Bullous Drug Reaction with Dipeptidyl Peptidase-4 (DPP-4) Inhibitors. Journal of Pharmacology and Pharmacotherapeutics, 13(1), 99–101. https://doi.org/10.1177/0976500X221080309