Role of Nrf2 Pathway Activation in Neurological Disorder: A Brief Review
Mohammad Zubair Baba1★, S. Gomathy1, Umair Wahedi1★ Corresponding author
- 1Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ootacamund, Tamil Nadu, India.
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Mohammad Zubair Baba
Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ootacamund, Tamil Nadu 643001, India.
Volume 13, Issue 3 · pp. 229–238 · PUBLISHED 2022 · DOI: 10.1177/0976500X221128855
ABSTRACT
Oxidative stress plays a crucial role in the emergence of numerous neurodegenerative diseases, with protein accumulation and mitochondrial damage, which result in neurological disorders. To minimize oxidative stress, several defensive mechanisms protect nerve cells by releasing antioxidants such as nuclear erythroid factor2 (Nrf2)-Kelch-like ECH- associated protein1 (Keap1) signaling pathway activation has been proved to be a prospective treatment to reduce oxidative stress and neuroinflammation for protection of neurons in a variety of neurological disorders. In this review, we focus beneficial role of Nrf2 in Alzheimer’s and Parkinson’s diseases. Nrf2 is proved to be a master regulator of antioxidants by releasing over 250 cytoprotective genes aimed at oxidative stress and neuroinflammation. In animal studies Nrf2 activation is proved to improve autophagy, mitochondrial biogenesis, and Suppression of inflammatory cytokinin which protects neuronal cells and inhibit progressive neurodegeneration.
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Baba, M. Z., Gomathy, S., & Wahedi, U. (2022). Role of Nrf2 Pathway Activation in Neurological Disorder: A Brief Review. Journal of Pharmacology and Pharmacotherapeutics, 13(3), 229–238. https://doi.org/10.1177/0976500X221128855