Volume 16, Issue 2

Mohammed K. Alshammari, Hind M. Al Osaimi, Norah F. Alshehri, Raneem F. Masoud, Alaa O. Abdulaal, Bashair Z. Al Qaidi

pp. 129–142 · DOI: 10.1177/0976500X241303306 · 2025

Background: Pediatric wellbeing and health outcomes are among the leading indicators of World Health Organization (WHO). Growing infections and risk of antibiotic resistance have appeared to be one of the main cause if m…

Aditya Kumar Bubna, Vinayak Viplav

pp. 143–163 · DOI: 10.1177/0976500X241303186 · 2025

Background: Apremilast is a phosphodiesterase-4 (PDE-4) inhibitor approved by the US-Food and Drug Administration (US-FDA) for the management of adult patients with plaque psoriasis (who are candidates for phototherapy/s…

Nagaraju Bandaru, Mohan Gandhi Bonthu, Alluri Pavani Gayatri, Shashikala Metri, Perli Kranti Kumar, Aneesha Addanki, Srilaksmi Nallapaty, Karri Swathi Priya, Dodda Tulase Nadhreddy, P. N. S. Gowravi

pp. 164–171 · DOI: 10.1177/0976500X241312726 · 2025

Background: Alzheimer’s disease (AD) is a complex neurological disorder characterized by neuronal loss and progressive cognitive decline. The disease progression is influenced by both environmental and genetic factors. R…

Nitya Krishnasamy, Ramya Ramadoss, Kochli Channapa Niranjan, Vikram S Amberkar, Haris Chandra Sahoo, Poorna Devadoss

pp. 172–184 · DOI: 10.1177/0976500X241299231 · 2025

Background: Oral squamous cell carcinoma (OSCC) is a prevalent form of head and neck cancer characterized by aggres-sive behavior and a poor prognosis. Conventional therapies have demonstrated limited effectiveness, unde…

Patrick A. Kalona, Uma Sundaresan, Chellappandian Muthiah, Ariharasivakumar Ganesan

pp. 185–192 · DOI: 10.1177/0976500X241299159 · 2025

Background: Cyclophosphamide is one of the most extensively used chemotherapeutic drugs and is employed to treat several malignancies. Cyclophosphamide often comes with several unpleasant side effects. The primary negati…

Ajay Gattani, Komal Khurade, Raakhi Tripathi, Rajmohan Seetharaman, Sharmila Jalgaonkar

pp. 193–201 · DOI: 10.1177/0976500X241299162 · 2025

Background: Animal models play a critical role in biomedical research, yet comprehensive data on the types and distribution of animals used in different research contexts are sparse. Objectives: This study aims to provid…

Aashish Joshi, Kailash Karande, Ravindra Gunaki

pp. 202–213 · DOI: 10.1177/0976500X241303572 · 2025

Background: Accidents are the major reasons causing hip bone fractures. These are due to reduced bone density due to aging effect which may cause fractures typically in proximal part of the femur bone. Objectives: The pu…

Mohammed Kanan, Abdullah Almotairi, Faisal Alrumaih, Reem Hammad, Mohammed Almotairi

pp. 214–225 · DOI: 10.1177/0976500X241303618 · 2025

Background: Bone marrow transplantation (BMT) is a crucial treatment for pediatric patients with various hematological, oncological, and genetic diseases. However, persistent thrombocytopenia (PT) post-transplantation po…

Akella Krishna Sowmya, Sunil Kumar Pandey

pp. 226–233 · DOI: 10.1177/0976500X241305442 · 2025

Background: Mental health issues in children and adolescents are quite significant. Despite their impact, research on psychiatric disorders in these age groups is limited. This study aims to evaluate the prescription pat…

Visha MG, Deepak Moses Ravindran, Balaji SK, Lekha Ashokkumar

pp. 234–242 · DOI: 10.1177/0976500X241306178 · 2025

Background: Periodontal disease is a chronic inflammatory disease that activates the innate immune response. Activation of the TREM-1 signaling pathway promotes the synthesis of inflammatory cytokines like interleukin-1 …

pp. 243–243 · DOI: 10.1177/0976500X251319617 · 2025