Drug-induced Acneiform Breakout in a Postpartum Psychosis Patient: A Case Report with Literature Review Deepalakshmi M1 , Sudharsan M2,3 , Rajalakshmi S4

Background: Acneiform eruption is a dermatological condition resembling acne vulgaris, with a similar clinical presentation that is often difficult to differentiate. Several medications like corticosteroids, anti-convulsants, anti-psychotics, anti-depressants, vitamin B12, and testosterone have all been linked to acneiform outbreaks. This case highlights the need for awareness of potential drug-induced dermatological side effects in the management of postpartum psychosis. Case Presentation: A 3-month postpartum psychosis female patient, around 30 years old, was admitted to the psychiatric department and treated with tablet Olanzapine and Clonazepam, but later developed new complaints of pain in the lower limbs and a burning sensation over the foot, and thus was treated with injection vitamin B complex. Within 30 min of receiving vitamin B complex, she developed cutaneous eruptions without comedones. A dermatological examination revealed a papulopustular eruption over her hand, neck, and face. Based on the subjective findings, the patient was diagnosed with vitamin B complex acneiform eruption. The treatment options start with discontinuing the offending medication, vitamin B complex. They were treated with tablet Ebastine 20 mg hora somni (HS), tablet Prednisolone 10 mg/day, and topical salicylic acid for a month, and gradually, the condition resolved. Conclusion: This report highlights a rare dermatological adverse event in a postpartum psychosis patient on vitamin B complex and Olanzapine. The sudden onset of acneiform eruptions underscores the importance of recognizing potential drug interactions and their dermatological manifestations, especially in postpartum patients, who may already be vulnerable to various physiological changes.