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Journal of Pharmacology and PharmacotherapeuticsNOW IN
Article

Adverse drug reaction profile of oseltamivir in children

Prashant S. Dalvi1★, Anil Singh1, Hiren R. Trivedi1, Suresh D. Mistry1, Bhadresh R. Vyas2★ Corresponding author

  1. 1Departments of Pharmacology, College, Jamnagar 361 008, Gujarat, India Research Paper.
  2. 2Pediatrics, MP Shah Medical College, Jamnagar 361 008, Gujarat, India Research Paper.

CORRESPONDENCE

Prashant S. Dalvi

Departments of Pharmacology, College, Jamnagar 361 008, Gujarat, India Research Paper.

Volume 2, Issue 2 · pp. 100–103 · PUBLISHED 2011 · DOI: 10.4103/0976-500X.81901

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ABSTRACT

Aim: To monitor and evaluate the pattern of ADRs to oseltamivir in pediatric population suffering from H1N1 infl uenza at a tertiary care hospital. Materials and Methods: Children offered oseltamivir for treatment and chemoprophylaxis were monitored for adverse events by direct questioning for symptoms and clinical examination on day 5 and day 10. Assessment of neurological events was done by asking the parents or guardians regarding development of specifi c symptoms. Adverse events obtained were analyzed for severity, causality and age-group wise. Results: Out of 191 children (median age, 3 years), 69 (36.1%) developed ADRs. Most common symptoms were vomiting (16.2%) followed by diarrhea (12.0%), ear disorders (8.9%), and insomnia (6.8%). The incidence of neuropsychiatric symptoms was 12.6% which were mild-to-moderate on severity scale. There was no signifi cant difference in the incidence of adverse events between children less than 1 year and other age groups. Conclusion: Oseltamivir is well tolerated in Indian children with suspected or confi rmed H1N1 infl uenza. Our study also indicates safety of oseltamivir in infants.

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    Dalvi, P. S., Singh, A., Trivedi, H. R., Mistry, S. D., & Vyas, B. R. (2011). Adverse drug reaction profile of oseltamivir in children. Journal of Pharmacology and Pharmacotherapeutics, 2(2), 100–103. https://doi.org/10.4103/0976-500X.81901