Comparison of efficacy and safety of two parenteral iron preparations in pregnant women

ABSTRACT

Objective: To compare the efficacy and safety with a fixed dose of two parenteral iron preparations, iron sucrose complex and iron sorbitol citric acid as per the current practice. Materials and Methods: A prospective randomized open label study was conducted. In this study, 60 pregnant women with hemoglobin less than 8.5 g/dl received a fixed dose of either IV iron sucrose or IM iron sorbitol citric acid therapy. The efficacy of the therapy was assessed by laboratory parameters such as hemoglobin, hematocrit, MCV, MCH, and serum ferritin level after 14 and 28 days. To assess the safety, adverse drug reactions with both the therapies were recorded. Results: Hemoglobin concentration increased significantly (P < 0.001) with respect to time in both the groups. The rise in the hemoglobin level in third and fourth weeks was significantly higher in iron sucrose (0.92 g/dl) than iron sorbitol citric acid therapy (0.56 g/dl). There was no significant change in the rise of the serum ferritin level after both the therapies. Adverse events were common with iron sorbitol citric acid therapy. However, no serious adverse drug reactions were observed. Conclusions: No significant difference in the efficacy of both of the therapy. However, adverse events and dropout rates were much more common in the group of pregnant women who received iron sorbitol citric acid.

KEYWORDS

• Iron deficiency anemia
• iron sucrose therapy
• iron sorbitol citric acid therapy
• pregnancy

Showing references and in-text citations exactly as published.

• DOI10.4103/0976-500X.103688Copy

RELATED ARTICLES

Matched on section and article type within this issue of JPP.

• Article · VOLUME 3, ISSUE 4The incidence and clinical relevance of drug interactions in pediatricsHasime Qorraj-Bytyqi, Rexhep Hoxha, Shaip Krasniqi, Elton Bahtiri, Valon Kransiqi · pp. 304–307Research PaperSame type: Article
• Article · VOLUME 3, ISSUE 4Intensive monitoring of adverse drug reactions in hospitalized patients of two medical units at a tertiary care teaching hospitalMaulik S. Doshi, Prakruti P. Patel, Samidh P. Shah, Ram K Dikshit · pp. 308–313Research PaperSame type: Article
• Article · VOLUME 3, ISSUE 4Comparison of the effectiveness and safety of cefpodoxime and ciprofloxacin in acute exacerbation of chronic suppurative otitis media: A randomized, open-labeled, phase IV clinical trialArijit Ghosh, Utpal Jana, Ajoy Khaowas, Saumik Das, Ananya Mandal, Nina Das · pp. 320–324Research PaperSame type: Article
• Article · VOLUME 3, ISSUE 4Reporting of adverse drug reactions in clinical trials published in Indian Medical/Dental journalsPurav Mody, Tamoghona Biswas, Jaykaran Charan, Deval Parikh · pp. 325–326Same type: Article