Volume 10, Issue 1

2019 · pp. 1–44 · 9 articles

Volume: 10
Issue: 1
Published: 2019
Pages: 1–44
Articles: 9
Sections: 4
ISSN: Print - 0976-500X, Online - 0976-5018
Journal: JPP

Review Article Research Paper Correspondence Case Report

In this issue

Review Article

Review
Structural Genomics in Drug Discovery: An Overview
Karri Sowjanya, Chandrashekaran Girish
pp. 1–6 · DOI: 10.4103/jpp.JPP_117_18 · Published 2019
Structural genomics, technology and methodology driven field has emerged in the past 20–25 years and mainly aims at coming up with as many three-dimensional structures of proteins as possible by combining experimental (X…

Research Paper

Article
Genotype and Allele Frequency of P450 Oxidoreductase *28 Gene Polymorphism in South Indian Population
R. Mirunalini, G. Pavithra, D. Benet Bosco Dhas, C. Adithan
pp. 7–10 · DOI: 10.4103/jpp.JPP_95_18 · Published 2019
Objective: To establish the normative frequency of POR *28 genetic variant in South Indian population. Methods: This study is a genetic epidemiological study conducted on healthy volunteers belonging to south India. A to…
Article
Comparison of Safety and Efficacy of Dexmedetomidine versus Propofol Sedation for Elective Awake Fiber-optic Intubation
Samarjit Dey, Tridip Jyoti Borah, Jaideep Sonowal, Debasis Pradhan, Md. Yunus, Priyanka Dev
pp. 11–15 · DOI: 10.4103/jpp.JPP_71_18 · Published 2019
Objective: To evaluate the safety and efficacy of dexmedetomidine versus propofol as a sedative modality for awake fiber-optic intubation (AFOI) in elective patients with anticipated difficult intubation. Materials and M…
Article
Antidepressants Modulate Behavioral, Biochemical, and Histological Alterations Induced by Chronic Aluminum Chloride Administration in Wistar Rats
Arshad Basha Shaik, Smita Shenoy, V. Anupama, K. G. Mohandas Rao, Arul Amuthan
pp. 16–21 · DOI: 10.4103/jpp.JPP_135_18 · Published 2019
Objective: To assess the effect of duloxetine and escitalopram on aluminum chloride (AlCl3)-induced memory impairment in rats. Materials and Methods: Thirty rats were used. Group-I (control) and Group-II (toxic control) …
Article
Pharmacokinetic Modeling of Propofol in Indian Children
B. Naveen Naik, Preethy J. Mathew, Smita Pattanaik, Venkateswari Muthukrishnan, Goverdhan Dutt Puri
pp. 22–32 · DOI: 10.4103/jpp.JPP_5_19 · Published 2019
Objective: To analyse the PK (pharmacokinetics) of propofol after single bolus dose in children undergoing elective general surgery and to establish a PK model of propofol after single bolus dose in children undergoing e…

Correspondence

Article
Targeted Spontaneous Reporting on Drug Safety Alerts Issued by Pharmacovigilance Programme of India: A New Origin of Pharmacovigilance in India
Prasad Thota, Shabir Sidhu, Bikash Medhi, Phulen Sarma, Ajay Prakash, Kalaiselvan Vivekanandan, Anusha Thota
pp. 33–34 · DOI: 10.4103/jpp.JPP_129_18 · Published 2019
However, our primary goal is to increase the safety alerts by utilizing already established AMC setup. There are some methods which are employed in the collection of ADRs, a few of which include enclosure of suspected AD…

Case Report

Article
Persistent Cryptococcal Meningitis Treated with Antiretroviral Therapy and Alternative Antifungals
Katie E. Barber, Svenja Albrecht, Kayla R. Stover
pp. 35–37 · DOI: 10.4103/jpp.JPP_103_18 · Published 2019
Because of the relative lack of information surrounding persistent cryptococcal meningitis, treatment presents a clinical dilemma. We report two patients who developed persistent cryptococcal meningitis that was nonrespo…
Article
Valproic Acid Induced Pancreatitis in an Arab Male
Ethar Abdelmageed Imam, Abdulrhman Idrees, Mohamed Izham Mohamed Ibrahim, Subish Palaian
pp. 38–41 · DOI: 10.4103/jpp.JPP_107_18 · Published 2019
Valproate, a commonly used antiepileptic, is known to cause pancreatitis, which may present days to years after initiation of therapy. A 20-year-old Arab male patient with electroencephalogram (EEG) confirmed epileptifor…
Article
Subconjunctival Bevacizumab for Recurrent Conjunctival Pyogenic Granuloma
Nirupama Kasturi, Tharini Senthamizh, Hanuman Srinivas Bheemanathi, K. Ramesh Babu
pp. 42–44 · DOI: 10.4103/jpp.JPP_123_18 · Published 2019
A 45-year-old male presented with a pyogenic granuloma of the bulbar conjunctiva of the left eye following a stick injury. It was a benign friable, hyperplastic, vascular lesion comprised of inflammatory cells and lobula…