Pseudocholinesterase Deficiency in an Indian Community
Maddi Ramaiah1★, Prudhivi Ramakrishna2★ Corresponding author
- 1Department of Pharmacognosy, Hindu College of Pharmacy, Guntur – 522002, AP, INDIA.
- 2Department of Pharmacy Practice, Dayananda Sagar University, Bangalore – 560078, Karnataka, INDIA.
CORRESPONDENCE
Maddi Ramaiah
Department of Pharmacognosy, Hindu College of Pharmacy, Guntur – 522002, AP, INDIA.
Received: 27-09-2016; Revised: 10-10-2016; Accepted: 09-11-2016.
Volume 3, Issue 1 · pp. 27–30 · PUBLISHED · DOI: 10.5530/jppcm.2017.1.6
ABSTRACT
Background: India, the seventh largest country, 3rd largest standing army and one of the oldest civilizations in the world, with a literacy rate of 74.04%. Indian population was a mixture of 46,73,034 categories of different castes and sub-caste each related to a specific occupation. Arya Vysya is a Hindu Indian caste with a total population of 22,952,000.Methods:Pseudocholinesterase is a glycoprotein enzyme with complex molecular structure synthesized in the liver and specifically hydrolyzes certain exogenous cholinesters. Pseudocholinesterase deficiency is a genetic enzyme abnormality or acquired alteration in the metabolism of choline esters in this patient may experience a paralysis of the respiratory muscles, to overcome this, required more time mechanically-assisted breathing. The presence of the genetic defect is not realized until one is exposed to succinylcholine or mivacurium.Results: Arya Vysya community people of India having deficiency of pseudocholinesterase is the most affected people than any other with homozygous mutation incidence rate of 2-4%. Very recent studies in 2016 reveal that malnutrition-induced pseudocholinesterase deficiency is also a possible etiology. Conclusion: It was suggested that the Arya Vysya Community people with a history of pseudocholinesterase deficiency should tell his or her doctor if when they undergo anesthesia for surgery to avoid potentially serious unwanted adverse effects.
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Ramaiah, M., & Ramakrishna, P. (). Pseudocholinesterase Deficiency in an Indian Community. Journal of Pharmacy Practice and Community Medicine, 3(1), 27–30. https://doi.org/10.5530/jppcm.2017.1.6