Article · Volume 1, Issue 4 · pp. 326–329
Hypoglycemic Effect of Leucas lavandulaefolia Willd in Alloxan-Induced Diabetic Rats
Chandrashekar KS1, Prasanna KS2
- 1Department of Pharmacognosy, NGSM Institute of Pharmaceutical Sciences, Paneer, Deralakatte, Mangalore, INDIA.
- 2Department of Community Medicine, Father Muller Medical College, Mangalore, INDIA.
Abstract
Leucas lavandulaefolia Willd. is mainly used in Indian folk medicine for the treatment of diabetes mellitus. The oral administration of 0.15, 0.20 and 0.25 g/kg of chloroform extract of the Leucas lavandulaefolia ß owers (LLFEt) for 30 days resulted in a signiÞ cant reduction in blood glucose, glycosylated hemoglobin and an increase in total hemoglobin, and the effect was highly signiÞ cant in the case of 0.25 g/kg. It also prevents decrease in body weight. Oral glucose tolerance test was also performed in experimental diabetic rats in which there was a signiÞ cant improvement in glucose tolerance in animals treated with LLFEt and the effect was compared with glibenclamide. Thus, the study shows that LLFEt has hypoglycemic action.
Keywords: Diabetes; glucose; hypoglycemic; Leucas lavandulaefolia
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