Article · Volume 10, Issue 2 · pp. 193–196

Antioxydant and Endotheliotropic Properties 4-Hydroxy-3,5-Di-Tret-Butyl Cinnamic Acid under Conditions of Experimental Brain Ischemia

Pozdnyakov DI¹, Voronkov AV¹, Zolotych DS¹, Arlt AV¹

¹Pyatigorsk Medical and Pharmaceutical Institute, A Branch of Volgograd State Medical University, Pyatigorsk, RUSSIA.

Abstract

Objective: To assess the effect of 4-hydroxy-3,5-di-tret-butyl cinnamic acid on the state of endothelial function under conditions of experimental cerebral ischemia.Materials and Methods: Antioxidant properties of 4-hydroxy-3,5-di-tret-butyl cinnamic acid and the effect of this compound on NO-synthase system activity and ADMA concentration were evaluated.Results: As a result, it has been found that the use of 4-hydroxy-3,5-di-tretbutyl cinnamic acid promotes reduction activity of catalase, glutathione peroxidase, superoxide dismutase and a decrease in the concentration of MDA and DC. In addition, the ability to modulate NO synthase system activity was established for this compound: an increase in eNOS activity by 114.2% (p <0.05), decrease activity of nNOS and iNOS by 60.6% (p <0.05) and 61.9% (p <0.05), respectively, decrease concentration of ADMA by 83.9% (p <0.05).Conclusion: The results of the conducted researches it is established that 4-hydroxy-3,5-di-tret-butyl cinnamic acid has antioxidant and NOS – regulating effect.

Keywords: Experimental ischemic stroke; Cinnamic acid derivatives; Antioxidants; Endothelium

The full text of this article is available as a PDF. Open the PDF.