Antioxydant and Endotheliotropic Properties 4-Hydroxy-3,5-Di-Tret-Butyl Cinnamic Acid under Conditions of Experimental Brain Ischemia
Pozdnyakov DI1★, Voronkov AV1, Zolotych DS1, Arlt AV1★ Corresponding author
- 1Pyatigorsk Medical and Pharmaceutical Institute, A Branch of Volgograd State Medical University, Pyatigorsk, RUSSIA.
CORRESPONDENCE
Pozdnyakov DI
Pyatigorsk Medical and Pharmaceutical Institute, A Branch of Volgograd State Medical University, Pyatigorsk, RUSSIA.
Received: 18-11-2017; Revised: 30-12-2017; Accepted: 08-01-2018.
Volume 10, Issue 2 · pp. 193–196 · PUBLISHED · DOI: 10.5530/jyp.2018.10.43
ABSTRACT
Objective: To assess the effect of 4-hydroxy-3,5-di-tret-butyl cinnamic acid on the state of endothelial function under conditions of experimental cerebral ischemia. Materials and Methods: Antioxidant properties of 4-hydroxy-3,5-di-tret-butyl cinnamic acid and the effect of this compound on NO-synthase system activity and ADMA concentration were evaluated. Results: As a result, it has been found that the use of 4-hydroxy-3,5-di-tretbutyl cinnamic acid promotes reduction activity of catalase, glutathione peroxidase, superoxide dismutase and a decrease in the concentration of MDA and DC. In addition, the ability to modulate NO synthase system activity was established for this compound: an increase in eNOS activity by 114.2% (p <0.05), decrease activity of nNOS and iNOS by 60.6% (p <0.05) and 61.9% (p <0.05), respectively, decrease concentration of ADMA by 83.9% (p <0.05). Conclusion: The results of the conducted researches it is established that 4-hydroxy-3,5-di-tret-butyl cinnamic acid has antioxidant and NOS – regulating effect.
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DI, P., AV, V., DS, Z., & AV, A. (). Antioxydant and Endotheliotropic Properties 4-Hydroxy-3,5-Di-Tret-Butyl Cinnamic Acid under Conditions of Experimental Brain Ischemia. Journal of Young Pharmacists, 10(2), 193–196. https://doi.org/10.5530/jyp.2018.10.43