Comparison of Bulk and Precipitation Polymerization Method of Synthesis Molecular Imprinted Solid Phase Extraction for Atenolol using Methacrylic Acid

Abstract

Objective: Atenolol is one of beta-blocker are prohibited as doping based on World Anti-Doping Agency (WADA). The purpose of this study was to the synthesis of molecular imprinted polymer (MIP) for extraction of atenolol from the sample.Method: This research compared the two of the method, bulk and precipitation polymerization. The MIP was successfully prepared from methacrylic acid as a functional monomer, ethyleneglycoldimethacrylate as a crosslinker, benzoyl peroxide as an initiator, butanol as a porogenic solvent with atenolol as a template molecule.Result: The result showed that the bulk polymerization method produces sorbents that have good adsorption capacity and small particle compare to the precipitation polymerization. Both methods were selective for atenolol.Conclusion: Generally, the MIP solid phase extraction is an alternative method for extraction atenolol from the sample.

Keywords: Atenolol; Molecular Imprinted Polymer; Solid Phase Extraction