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Article

Comparison of Bulk and Precipitation Polymerization Method of Synthesis Molecular Imprinted Solid Phase Extraction for Atenolol using Methacrylic Acid

Rimadani Pratiwi1, Sandra Megantara1, Driyanti Rahayu1, Indraswari Pitaloka1, Aliya Nur Hasanah1★★ Corresponding author

  1. 1Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor 45363, INDONESIA.

CORRESPONDENCE

Aliya Nur Hasanah

Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor 45363, INDONESIA.

aliya.n.hasanah@unpad.ac.id

Received: 15-11-2018; Revised: 05-12-2018; Accepted: 12-12-2018.

Volume 11, Issue 1 · pp. 12–16 · PUBLISHED · DOI: 10.5530/jyp.2019.11.3

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ABSTRACT

Objective:Atenolol is one of beta-blocker are prohibited as doping based on World Anti-Doping Agency (WADA). The purpose of this study was to the synthesis of molecular imprinted polymer (MIP) for extraction of atenolol from the sample. Method:This research compared the two of the method, bulk and precipitation polymerization. The MIP was successfully prepared from methacrylic acid as a functional monomer, ethyleneglycoldimethacrylate as a crosslinker, benzoyl peroxide as an initiator, butanol as a porogenic solvent with atenolol as a template molecule. Result:The result showed that the bulk polymerization method produces sorbents that have good adsorption capacity and small particle compare to the precipitation polymerization. Both methods were selective for atenolol. Conclusion:Generally, the MIP solid phase extraction is an alternative method for extraction atenolol from the sample.

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    Pratiwi, R., Megantara, S., Rahayu, D., Pitaloka, I., & Hasanah, A. N. (). Comparison of Bulk and Precipitation Polymerization Method of Synthesis Molecular Imprinted Solid Phase Extraction for Atenolol using Methacrylic Acid. Journal of Young Pharmacists, 11(1), 12–16. https://doi.org/10.5530/jyp.2019.11.3