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Journal of Young Pharmacists volume 11, issue 1 cover
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Cover: Journal of Young Pharmacists

Journal of Young Pharmacists

Volume 11, Issue 1

· pp. 1–116 · 25 articles

Volume
11
Issue
1
Published
Pages
1–116
Articles
25
Sections
3
ISSN
Print - 0975-1483 | Online - 0975-1505
Journal
JYP
Original ArtcileShort CommunicationCase Report

In this issue

Original Artcile

  1. Article

    Fast Dissolving Oral Film of Piroxicam: Solubility Enhancement by forming an Inclusion Complex with β-cyclodextrin, Formulation and Evaluation

    Shripathy Dharmasthala, Addai Ramakrishna Shabaraya, Gladson Simon Andrade, Ravi Gundadka Shriram, Srinivas Hebbar, Akhilesh Dubey

    pp. 1–6 · DOI: 10.5530/jyp.2019.11.1 · Published

    Objective:Piroxicam is a long-acting potent nonsteroidal anti-inflammatory drug (NSAID) which has a very low solubility in Gastrointestinal (GI) fluids results in poor bioavailability after oral administration. The prese…

  2. Article

    Eudragit S-100 Encapsulated Chitosan Coated Liposomes Containing Prednisolone for Colon Targeting: In vitro, Ex vivo and In vivo Evaluation

    Mascarenhas Shanon Ben, Koland Marina, Ghetia Sawan Mukund

    pp. 7–11 · DOI: 10.5530/jyp.2019.11.2 · Published

    Objective:The present study was carried out to design an efficient formulation to target the drug loaded liposomes exclusively to the inflamed colonic region by protecting the payload from releasing in the upper gastro i…

  3. Article

    Comparison of Bulk and Precipitation Polymerization Method of Synthesis Molecular Imprinted Solid Phase Extraction for Atenolol using Methacrylic Acid

    Rimadani Pratiwi, Sandra Megantara, Driyanti Rahayu, Indraswari Pitaloka, Aliya Nur Hasanah

    pp. 12–16 · DOI: 10.5530/jyp.2019.11.3 · Published

    Objective:Atenolol is one of beta-blocker are prohibited as doping based on World Anti-Doping Agency (WADA). The purpose of this study was to the synthesis of molecular imprinted polymer (MIP) for extraction of atenolol …

  4. Article

    Evaluation of Silver Nanoparticles Addition in Periodontal Dressing for Wound Tissue Healing by 99mTc-ciprofloxacin

    Budhi Cahya Prasetyo, Rizky Juwita Sugiharti, Isa Mahendra, Iim Halimah, Eva Maria Widyasar, Nunung Rusminah`, Indra Mustika

    pp. 17–20 · DOI: 10.5530/jyp.2019.11.4 · Published

    Objective: Periodontal dressing is a protective material that is used on post-surgical periodontal to protect the surface of the wound and provides a comfort sense to patient. This study was conducted to determine the ef…

  5. Article

    Development and Validation of an RP-HPLC Method for Determination of Solasodine, a Steroidal Alkaloid

    Shahram Kalantari Khandani, Mitra Mehrabani, Fariba Sharififar, Abbas Pardakhty, Mostafa Pournamdari, Mahboobeh Pakravanan

    pp. 21–25 · DOI: 10.5530/jyp.2019.11.5 · Published

    Objective:The aim of the present study was to optimize an RP-HPLC method for determination of solasodine, a steroidal alkaloid with various pharmacologic properties, in herbal medicinal preparations. Methods: Various chr…

  6. Article

    UV-Vis Spectroscopy to Enable Determination of the Dissolution Behavior of Solid Dispersions Containing Curcumin and Piperine

    Yosi Bayu Murti, Yustina Sri Hartini, Wouter Leonardus Joseph Hinrichs, Henderik Willem Frijlink, Dewi Setyaningsih

    pp. 26–30 · DOI: 10.5530/jyp.2019.11.6 · Published

    Objective: Curcumin and piperine exibit poor aqueous solubility and dissolution. Solid dispersion technology is a promising way to improve dissolution of lipophilic compounds. Therefore, to investigate the dissolution be…

  7. Article

    Host-Guest Interactions of α−Mangostin with (α,β,γ)− Cyclodextrins: Semi-Empirical Quantum Mechanical Methods of PM6 and PM7

    Doni Dermawan, Nasrul Wathoni, Muchtaridi Muchtaridi

    pp. 31–35 · DOI: 10.5530/jyp.2019.11.7 · Published

    Objective: This study aimed to investigate the molecular interactions, geometrical properties, encapsulation process and calculated energy of the inclusion complexes system between α−mangostin (guest) with α−cyclodextrin…

  8. Article

    Gene Expression Levels of Selected Factors in Monocytic Leukemia Cell Line THP-1 Upon Treatment with n-butanol Extract of Atractylis flava Desf against Cancer

    Melakhessou Mohamed Akram, Benkiki Naima, Marref Salah Eddine, Olivier Joubert, Zahra Manel Doumandji, Ramia Safar

    pp. 36–39 · DOI: 10.5530/jyp.2019.11.8 · Published

    Objective:The aim of the present study was to screen the anticancer activity of Atractylis flava Desf in butanolic extract (AFBE). In addition, we attempted to investigate the gene expression levels of seven relevant gen…

  9. Article

    Protective Efficacy of Asparagus racemosus Root Extract and Isoprinosine against Ionizing Radiation - induced Clastogenicity and Toxicity in Swiss Albino Mice

    Sharmila Kameyanda Poonacha, Satheesh Kumar Bhandary Bavabeedu, Ronald Fernandes, Suchetha Kumari Nalilu, Vadisha Srinivas Bhat, Jayarama Shetty Kolakebail, Jerish Mangattu Jose, Alex John Peter

    pp. 40–45 · DOI: 10.5530/jyp.2019.11.9 · Published

    Objective:We aimed to evaluate anticlastogenic and radioprotective potential of Asparagus racemosus root extract (ARE) and Isoprinosine (IPR) against electron beam radiation (EBR) induced clastogenicity and toxicity in S…

  10. Article

    Anthocyanin-rich Buni-berry (Antidesma bunius) Extract Increases Paraoxonase 1 Gene Expression in BALB/c Mice Fed with a High-fat Diet

    Suryani Tawali, Suryani As’ad, Mochammad Hatta, Agussalim Bukhari, Nur Khairi, Yusnita Rifai, Ressy Dwiyanti

    pp. 46–50 · DOI: 10.5530/jyp.2019.11.10 · Published

    Objective:The aim of this study was to determine the effectiveness of buni-berry (Antidesma bunius) extract to increase PON1 mRNA expression in BALB/c mice fed with a high-fat diet. Methods: Twenty, thirty-weeks old male…

  11. Article

    Anti-cancer Activity and Gene Expression Responses to Methanol Extract of Gladiolus segetum in THP-1 Human Monocytic Leukemia Cells

    Marref Salah Eddine, Benkiki Naima, Melakhessou Mohamed Akram, Olivier Joubert, Zahra Manel Doumandji, Ramia Safar

    pp. 51–55 · DOI: 10.5530/jyp.2019.11.11 · Published

    Objective:To Evaluate the viability of cells against exposure to the Methanol Extract of Gladiolus segetum (MEGS) by various colorimetric detection tests (Alamar Blue, WST-1) and the trypan blue exclusion test in Human L…

  12. Article

    Induction of Epithelial Ovarian Cancer by Implantation of 7,12-dimethylbenz(a)athracene (DMBA) Coated Silk in Rats.

    Ni Made Dwi Sandhiutam, Wawaimuli Aroza, Melva Louisa, Deni Rahmat, Puspita Eka Wuyung, Mokhamad Fakhrul Ulum

    pp. 56–61 · DOI: 10.5530/jyp.2019.11.12 · Published

    Objective:This research aims to get the relevant animal model for epithelial ovarian cancer and ultrasonography approach to detect volume and size of ovarian cancer. Methods:Induction of ovarian cancer in rats was carrie…

  13. Article

    In vitro Immunomodulatory Effect of Lawsone Methyl Ether on Innate Immune Response of Human Phagocytes

    Abdi Wira Septama, Pharkphoom Panichayupakaranant, Ibrahim Jantan

    pp. 62–66 · DOI: 10.5530/jyp.2019.11.13 · Published

    Objectives:Lawsone methyl ether (LME) is a naphtoquinone compound found in the leaf of Impatiens balasamina L. It has been semi synthesized by methylation of lawsone. This compound possessed several pharmacological prope…

  14. Article

    Assessment of Success Rate of Directly Observed Treatment Short-Course (DOTS) in Tuberculosis Patients of South India

    Ramakrishna Prudhivi, Siva Reddy Challa, Basaveswara Rao MV, Veena G, Bhaskara Rao N, Hema Manogna Narne

    pp. 67–72 · DOI: 10.5530/jyp.2019.11.14 · Published

    Objective: To assess the success rate of DOTS for tuberculosis patients and the secondary objective was to identify the factors associated with unsuccessful treatment outcome. Methods: A retrospective study was conducted…

  15. Article

    Retrospective Drug Utilization of Cardiovascular Drugs in A Tertiary Healthcare Setting in Malaysia

    Ai Ching Yap, Thamby Sam Aaseer, Yen Ping Ng

    pp. 73–76 · DOI: 10.5530/jyp.2019.11.15 · Published

    Objective:The general objective of this study was to analyse the utilization patterns of cardiovascular drugs among a sample of patients in a tertiary healthcare setting during the preceding two years. Methodology:This s…

  16. Article

    Analysis of Drug-Related Problems Identified by Future Pharmacists in Medical Wards of Tertiary Hospitals in the State of Pahang, Malaysia

    Mohamed Hassan Elnaem, Nor Ilyani Mohamed Nazar, Norny Syafinaz Ab Rahman, Shazia Jamshed

    pp. 77–81 · DOI: 10.5530/jyp.2019.11.16 · Published

    Objective:Clinical attachments undertaken by pharmacy students in Malaysia are one of the important platforms in order to prepare future candidates for patient-centred pharmacy practice. The lack of data regarding the id…

  17. Article

    Adverse Drug Reactions and Medication Errors: A Quantitative Insight in Aden, Yemen

    Mohammed Alshakka, Gamila Mohammed Abdo Saeed, Heyam Ali, Sunil Kumar Prajapati, Mohamed Izham Ibrahim

    pp. 82–87 · DOI: 10.5530/jyp.2019.11.17 · Published

    Objectives: The study aimed to detect and assess common prescribing and dispensing Medication Errors (MEs); frequency of Adverse Drug Reactions (ADRs); the drugs causing frequent ADRs; and the typical types of ADRs. Meth…

  18. Article

    Investigating True β-lactam Allergy in the Outpatient Allergy Clinics at a Public Children’s Hospital, Ceará, Brazil

    Eudiana Vale Francelino, Sarah Resende Araújo, Janaira Fernandes Severo Ferreira, Fabiane Milena de Castro Araújo, Kaila Barroso Medeiros Bulgarelli, Patrícia Barros Nunes, Aparecida Tiemi Nagao-Dias

    pp. 88–91 · DOI: 10.5530/jyp.2019.11.18 · Published

    Objective:The aim of the study was to investigate true β-lactam allergy at a public pediatric hospital. Material and Methods:Children and adolescents with allergy symptoms were referred to the Allergy and Immunology Serv…

  19. Article

    Reduced Vitamin D Levels and Iron Deficiency Anaemia in Pregnant Women: An Evolving Correlation

    Roopa Satyanarayan Basutkar, Thomas Eipe, Tenzin Tsundue, Divya Perumal, Sivasankaran Ponnusankar

    pp. 92–96 · DOI: 10.5530/jyp.2019.11.19 · Published

    Aim: To elucidate correlation between serum vitamin D levels and iron status in pregnant women and to generate hypothesis for supplementation of vitamin D in iron deficient patients. Methods:It is a prospective observati…

  20. Article

    Storage and Safe Disposal of Unwanted/Unused and Expired Medicines: A Descriptive Cross-Sectional Survey among Indian Rural Population

    Ponnusankar Sivasankaran, Elmutaz Belah Mohammed, Navamani Ganesan, Raja Durai

    pp. 97–100 · DOI: 10.5530/jyp.2019.11.20 · Published

    Objective:Isoniazid (INH) is metabolized by N-acetyl transferase-2 into Background: Over recent years, an increase in the use of pharmaceutical products has been observed. The lack of clear guidelines in India for the pa…

  21. Article

    Clozapine Disrupts Endothelial Nitric Oxide Signaling and Antioxidant System for its Cardiovascular Complications

    Gayathri M Nair, Dona Sheba Skaria, Teenu James, S K Kanthlal

    pp. 105–107 · DOI: 10.5530/jyp.2019.11.22 · Published

    Objective:Many drugs in current practice require additional safety labels in order to prevent potential risks to the major organ system. Psychotropic agent clozapine has been reported to produce myocarditis and other car…

Short Communication

  1. Communication

    Ex vivo and in silico Molecular Docking Studies of Aldose Reductase Inhibitory Activity of Apigenin from Morus indica L.

    Satish Anandan, Murali Mahadevamurthy, Chandra C, Asna Urooj

    pp. 101–104 · DOI: 10.5530/jyp.2019.11.21 · Published

    Objective: An investigation on Aldose Reductase Enzyme (ALR) inhibitory activity of apigenin (API) isolated from Morus indica L. was evaluated by ex vivo and molecular docking studies. Materials and Methods: The inhibito…

Case Report

  1. Article

    Case Report on a Rare Adverse Drug Reaction of Cefotaxime Induced Subacute Cutaneous Lupus Erythematosus

    Kabakama`C Clement, Nandhi Nalini

    pp. 108–111 · DOI: 10.5530/jyp.2019.11.23 · Published

    Drug Induced lupus erythematosus is a variant of lupus erythematosus that resolves within days to months after withdrawal of the culprit drug in a patient. DILE can sometimes arise months to years after the exposure to d…

  2. Article

    Ataxia, Manifestation of Phenytoin Toxicity: A Case Report

    Singh Juhi, Tyagi Shubham Singh, Jangra Manjeet Singh, Rashid Muhammed, Chhabra Manik, Tripathi Raman Kumar

    pp. 112–113 · DOI: 10.5530/jyp.2019.11.24 · Published

    Phenytoin is a choice of drug for the treatment of epilepsy. It is categorized under drugs with narrow therapeutic range. Adverse effects of phenytoin observed in patients are gum hypertrophy, dystonia, myoclonus, abnorm…

  3. Article

    Laurence Moon Bardet Biedl Syndrome with Maturity Onset Diabetes of the Young (Mody) - Case Report

    Krishna Kumar Dhakchinamoorthi, John Thomas Palathingal, Saroja Sreenivasan

    pp. 114–116 · DOI: 10.5530/jyp.2019.11.25 · Published

    Laurence-Moon-Bardet-Biedl syndrome (LMBBS) is an inherited genetic condition combination of two distinct disorders: Biedl-Bardet syndrome (BBS) and Laurence-Moon syndrome (LMS). BBS is characterized by polydactyly finge…