jrnls.org logo
Submit

BROWSE ALL JOURNALS

SEE ALL 19 JOURNALS
Journal of Young PharmacistsNOW IN
Article

Enhanced Solubility of Modafinil via Solubilization Techniques

Juturu Thimmasetty1, Tanmoy Ghosh2★, Shashank Nayak Nagar1, Shwetha Kamath1, Shanmuganathan Seetharaman3, Abbas Kumai Mohamed1★ Corresponding author

  1. 1Department of Pharmaceutics, Bapuji Pharmacy College, Davangere, Karnataka, INDIA.
  2. 2Department of Pharmaceutics, Faculty of Pharmacy, MS Ramaiah University of Applied Sciences, Bangalore, Karnataka, INDIA.
  3. 3Department of Pharmaceutics, Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research (Deemed to be University), Porur, Chennai, Tamil Nadu, INDIA.

CORRESPONDENCE

Tanmoy Ghosh

Department of Pharmaceutics, Faculty of Pharmacy, MS Ramaiah University of Applied Sciences, Bangalore, Karnataka, INDIA.

tanmoy.ps.ph@msruas.ac.in

Received: 01-01-2020; Revised: 20-02-2020; Accepted: 10-03-2020.

Volume 12, Issue 2 · pp. 129–134 · PUBLISHED · DOI: 10.5530/jyp.2020.12.26

View on JYP original site ↗

ABSTRACT

Objectives:The objective of the study was to compare solubilization approaches, namely cosolvency, micelle solubilization, complexation, pH adjustment and hydrotrophy, on BCS class II drug modafinil solubility. Methods:Altered solubility study of modafinil was carried out in numerous water-cosolvent mixtures. Similar type of study was performed using different ionic and non-ionic surfactants using phase solubility analysis. Furthermore, solubility behavior with two cyclodextrins namely beta cyclodextrin and maltodextrin were examined. Solubility studies were conducted in buffers of different pH ranging from 1.2 to 8 at different temperatures (25°C and 37°C). The effect of hydrotrophy on the solubility of modafinil was also studied. Results:Outcomes showed that ethanol is depicted to enhance solubility by greater height. It is found that ionic surfactants were better solubilizers than non-ionic surfactants. The capacity of solubilization is depicted to enhance with rise in hydrocarbon chain length of surfactant, denoting that hydrocarbon core of micelles as the center of solubilization. Highest solubility and binding constants were achieved with use of beta cyclodextrins followed by maltodextrins. The buffers of pH 2 and pH 3 have shown highest solubility when compared to others. Sodium thiocyanate salt had shown highest solubility of the drug. Conclusion:As a consequence, the study provides dataset so as to contrast effects of numerous solubilizers on modafinil solubility and also gives an insight of the mode of solubilization by aforementioned techniques.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Thimmasetty, J., Ghosh, T., Nagar, S. N., Kamath, S., Seetharaman, S., & Mohamed, A. K. (). Enhanced Solubility of Modafinil via Solubilization Techniques. Journal of Young Pharmacists, 12(2), 129–134. https://doi.org/10.5530/jyp.2020.12.26