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Journal of Young PharmacistsNOW IN
Article

Development of Standard Operating Procedures (SOPs) of a Polyherbal Formulation Qurṣ-i Muṣaffī Recommended for the Treatment of Skin Diseases

Md Sanaul Moin1★, Javed Inam Siddiqui1, Mohammed Abdul Rasheed Naikodi2, Shayni Khan1, Md Aftab Alam1, Faiza Khatoon3★ Corresponding author

  1. 1P.G. Department of Ilmul Advia (Pharmacology), National Research Institute of Unani Medicine for Skin Disorders (NRIUMSD), Hyderabad, Telangana, INDIA.
  2. 2Drug Standardization Research Unit, National Research Institute of Unani Medicine for Skin Disorders (NRIUMSD), Hyderabad, Telangana, INDIA.
  3. 3P.G. Department of Moalajat (Medicine), National Research Institute of Unani Medicine for Skin Disorders (NRIUMSD), Hyderabad, Telangana, INDIA.

CORRESPONDENCE

Md Sanaul Moin

P.G. Department of Ilmul Advia (Pharmacology), National Research Institute of Unani Medicine for Skin Disorders (NRIUMSD), Hyderabad, Telangana, INDIA.

mdsanaulmoin@gmail.com

Received: 21-06-2022; Revised: 05-09-2022; Accepted: 16-09-2022.

Volume 15, Issue 1 · pp. 74–82 · PUBLISHED · DOI: 10.5530/097515050409

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ABSTRACT

Background:Despite increasing acceptability and effectiveness, Unani Medicine has been widely criticized for lack of quality assurance and poor presentation. Therefore, in order to ensure the production of high-quality drugs, good manufacturing practices and the development of scientifically Standard Operating Procedures (SOPs) are necessary. The purpose of this study was to create SOPs for a polyherbal formulation Qurṣ-i Muṣaffī (QM) regarding its binder, temperature and duration of drying, as well as an assessment of its Mizāj (temperament). Materials and Methods: 18 batches of QM were prepared under different conditions (binder, temperature and duration of drying). Powder of particle sizes 150 μm, gum acacia mucilage (10%, 15% and 20% w/w) were used as a binder, at 60°C temperature for 20 and 30 min during the process of granulation and after compression 20 min only. Results:Data of the study revealed that the final batch of QM with particle size 150 μm, gum acacia (20 %) as the binder, temperature 60°C for 30 min for granules and 20 min after compression were found appropriate. The temperament (Mizāj) of the QM was assessed through method described by renowned Unani scholar Al-Kindῑ and found to be moderate degree in hot property and second degree in dry property. Conclusion: The obtained results of final batches of QM can be adopted as the SOPs for future references in terms of process standardization and reproducibility of the drug.

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    Moin, M. S., Siddiqui, J. I., Naikodi, M. A. R., Khan, S., Alam, M. A., & Khatoon, F. (). Development of Standard Operating Procedures (SOPs) of a Polyherbal Formulation Qurṣ-i Muṣaffī Recommended for the Treatment of Skin Diseases. Journal of Young Pharmacists, 15(1), 74–82. https://doi.org/10.5530/097515050409