Innovative Formulation of Tridax procumbens Ethosomes: A Study on Properties and Drug Release Kinetics

ABSTRACT

Background: Tridax procumbens is an herbal plant that has been used for many centuries. It has shown promise in treating various medical ailments, including skin infections, burns, and wounds. The plant has several active ingredients, such as triterpenes, ursolic acid, quercetin, and tridaxin, all of which have potent anti-inflammatory, antibacterial, antioxidant, and wound-healing qualities. Materials and Methods: Lipid-based nanocarriers called ethosomes have drawn much interest in studying six formulations with varying amounts of ethanol and lecithin created in the study. Numerous criteria, including globule size, shape, zeta potential, entrapment efficiency, and in vitro drug release, were evaluated in detail for the ethosomal formulations. Results: The study's findings showed that every formulation had spherical and unilamellar characteristics, with entrapment efficiencies ranging from 57 % to 75 %, globule sizes between 122.6 to 910.3 nm, and zeta potentials between -25.06 to -52 mV. The invitro release tests demonstrated the medication's consistent, long-term release from ethosomal vesicles. Conclusion:The results of further evaluation studies indicate that the F5 ethosomal formulation, which contains quercetin as an active ingredient, had the highest levels of entrapment efficiency. The release kinetics were consistent with a Fickian zero-order drug release and diffusion pattern, showing both penetration and prolonged drug action.

KEYWORDS

• Tridax procumbens
• Quercetin
• Ethosome
• Globule size
• Zeta potential

Showing references and in-text citations exactly as published.

• DOI10.5530/jyp.2024.16.3Copy

RELATED ARTICLES

Matched on section and article type within this issue of JYP.

• Article · VOLUME 16, ISSUE 1Cardioprotective Potential of Cardiboost, a Standardized Extract from Terminalia arjuna Bark against H2O2 Induced Oxidative Stress in H9c2 CardiomyocytesKuluvar Gouthamchandra, Heggar Venkataramana Sudeep, Amritharaj Amritharaj, Anusha Sathish, Lingaraju Harakanahalli Basavegowda, T. P Prasanna Kumar, Shyam Prasad Kodimule · pp. 10–16Original ArtcileSame type: Article
• Article · VOLUME 16, ISSUE 1Synthetic and in vivo Antiepileptic Activity of “Benzene Sulfonic Acid and its Derivatives”Rohit Jaysing Bhor, Sanket Satish Patare, Rahul Bapusaheb Shirole, Karan Suresh Kadam, Mahesh Hari Kolhe, Rajshree Ghogare · pp. 24–32Original ArtcileSame type: Article
• Article · VOLUME 16, ISSUE 1Delta-9-tetrahydrocannabinol Ameliorates D-galactose/ Aluminium Chloride-Induced Alzheimer’s-Like Cognitive Deficit in Rats via Neurogenesis in their HippocampusFatin Nadzirah Zakaria, Mohamad Aris Mohd Moklas, Mohamad Taufik Hidayat Baharuldin, Che Norma Mat Taib, Hasiah Ab Hamid, Hafizah Abdul Hamid, Samaila Musa Chiroma · pp. 33–41Original ArtcileSame type: Article
• Article · VOLUME 16, ISSUE 1Metoprolol and Bisoprolol in Coronary Artery Disease: An Observational Prospective Cross-Sectional StudyRajesh A. Maheshwari, Priyank Rathi, Jay Shah, Ritu Patel, Cinosh Mathew, Hemrajsingh Rajput, Rajesh Hadia · pp. 42–49Original ArtcileSame type: Article