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JYP · Lens · Anti-tumor Activity of N4 [(E)-1-(2-hydroxyphenyl) Methylidene], N4-[(E)-2-Phenylethylidene], N4 [(E,2E)-3-Phenyl-2-propenylidene], and N4[(E)ethylidene] Isonicotinohydrazide on K562 and Jurkat Cell Lines

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Article · Volume 2, Issue 4 · pp. 399–402

Anti-tumor Activity of N4 [(E)-1-(2-hydroxyphenyl) Methylidene], N4-[(E)-2-Phenylethylidene], N4 [(E,2E)-3-Phenyl-2-propenylidene], and N4[(E)ethylidene] Isonicotinohydrazide on K562 and Jurkat Cell Lines

Shabani F1, Ghammamy S2, Jahazi A3, Siavoshifar F4

  1. 1Department of Chemistry, Islamic Azad University, Young Researchers Club, IRAN.
  2. 2Department of Chemistry, IRAN.
  3. 3Medicinal Sciences, Islamic Azad University, IRAN.
  4. 4Moravvej Student-Research Institute, Ardabil Branch, Ardabil, IRAN.

Abstract

Using the water eliminated mechanism, reactions of 4-pyridinecarboxylic acid hydrazide and salicylaldehyde, benzaldehyde, cinnamaldehyde, and formaldehyde afforded the corresponding N4[(E)-1-(2-hydroxyphenyl) methylidene] (NHPM), N4-[(E)-2-phenylethylidene] (NPI), N4[(E,2E)-3-phenyl-2-propenylidene] (NPPI), and N4[(E) ethylidene] (NEI) isonicotinohydrazide, in high yields, after several minutes, as reported. These new compounds have shown antitumor activity against two kinds of cancer cells, which are K562 (human chronic myeloid leukemia) and Jurkat (human T lymphocyte carcinoma).

Keywords: 4-pyridinecarboxylic acid hydrazide; isonicotinohydrazide; Jurkat; K562

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