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Anti-tumor Activity of N4 [(E)-1-(2-hydroxyphenyl) Methylidene], N4-[(E)-2-Phenylethylidene], N4 [(E,2E)-3-Phenyl-2-propenylidene], and N4[(E)ethylidene] Isonicotinohydrazide on K562 and Jurkat Cell Lines

Shabani F1, Ghammamy S2★, Jahazi A3, Siavoshifar F4★ Corresponding author

  1. 1Department of Chemistry, Islamic Azad University, Young Researchers Club, IRAN.
  2. 2Department of Chemistry, IRAN.
  3. 3Medicinal Sciences, Islamic Azad University, IRAN.
  4. 4Moravvej Student-Research Institute, Ardabil Branch, Ardabil, IRAN.

CORRESPONDENCE

Ghammamy S

Department of Chemistry, IRAN.

shghamami@ikiu.ac.ir or

Volume 2, Issue 4 · pp. 399–402 · PUBLISHED · DOI: 10.4103/0975-1483.71638

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ABSTRACT

Using the water eliminated mechanism, reactions of 4-pyridinecarboxylic acid hydrazide and salicylaldehyde, benzaldehyde, cinnamaldehyde, and formaldehyde afforded the corresponding N4[(E)-1-(2-hydroxyphenyl) methylidene] (NHPM), N4-[(E)-2-phenylethylidene] (NPI), N4[(E,2E)-3-phenyl-2-propenylidene] (NPPI), and N4[(E) ethylidene] (NEI) isonicotinohydrazide, in high yields, after several minutes, as reported. These new compounds have shown antitumor activity against two kinds of cancer cells, which are K562 (human chronic myeloid leukemia) and Jurkat (human T lymphocyte carcinoma).

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    F, S., S, G., A, J., & F, S. (). Anti-tumor Activity of N4 [(E)-1-(2-hydroxyphenyl) Methylidene], N4-[(E)-2-Phenylethylidene], N4 [(E,2E)-3-Phenyl-2-propenylidene], and N4[(E)ethylidene] Isonicotinohydrazide on K562 and Jurkat Cell Lines. Journal of Young Pharmacists, 2(4), 399–402. https://doi.org/10.4103/0975-1483.71638