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Article

Development of a Floating Dosage Form of Ranitidine Hydrochloride by Statistical Optimization Technique

Jain S1★, Srinath MS1, Narendra C2, Reddy SN1, Sindhu A3★ Corresponding author

  1. 1Department of Pharmaceutics, Government College of Pharmacy, No. 2, P. Kalinga Rao Road, Bangalore, INDIA.
  2. 2Department of Pharmaceutics, VV Pura Institute of Pharmaceutical Sciences, Bangalore, INDIA.
  3. 3Department of Pharmaceutics, M.S. Ramaiah College of Pharmacy, MSR Nagar, MSRIT Post, Bangalore, INDIA.

CORRESPONDENCE

Jain S

Department of Pharmaceutics, Government College of Pharmacy, No. 2, P. Kalinga Rao Road, Bangalore, INDIA.

bksachinjain@rediffmail.com

Volume 2, Issue 4 · pp. 342–349 · PUBLISHED · DOI: 10.4103/0975-1483.71619

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ABSTRACT

The objective of this study was to evaluate the effect of formulation variables on the release properties, floating lag time, and hardness, when developing floating tablets of Ranitidine hydrochloride, by the statistical optimization technique. The formulations were prepared based on 32 factorial design, with polymer ratio (HPMC 100 KM: Xanthan gum) and the amount of aerosil, as two independent formulation variables. The four dependent (response) variables considered were: percentage of drug release at the first hour, T50% (time taken to release 50% of the drug), floating lag time, and hardness of the tablet. The release profile data was subjected to a curve fitting analysis, to describe the release mechanism of the drug from the floating tablet. An increase in drug release was observed with an increase in the polymer ratio, and as the amount of aerosil increased, the hardness of the tablet also increased, without causing any change in the floating lag time. The desirability function was used to optimize the response variables, each having a different target, and the observed responses were in accordance with the experimental values. The results demonstrate the feasibility of the model in the development of floating tablets containing Ranitidine hydrochloride.

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    S, J., MS, S., C, N., SN, R., & A, S. (). Development of a Floating Dosage Form of Ranitidine Hydrochloride by Statistical Optimization Technique. Journal of Young Pharmacists, 2(4), 342–349. https://doi.org/10.4103/0975-1483.71619