Journal of Young Pharmacists
Volume 2, Issue 4
· pp. 339–436 · 23 articles
- Volume
- 2
- Issue
- 4
- Published
- Pages
- 339–436
- Articles
- 23
- Sections
- 12
- ISSN
- Print - 0975-1483 | Online - 0975-1505
- Journal
- JYP
In this issue
Editorial
- Forum Article
Uncovering Negative Results: Introducing an Open Access Journal “Journal of Pharmaceutical Negative Results”
Vipra Kundoor, Mueen Ahmed KK
pp. 339–341 · DOI: 10.4103/0975-1483.71618 · Published
Drug discovery nowadays is a highly innovative process by which new drugs are discovered and/or designed. It is expected that in the year 2010, at least 50% of all new approved drugs will come from the biopharmaceutical …
Pharmaceutics
- Article
Development of a Floating Dosage Form of Ranitidine Hydrochloride by Statistical Optimization Technique
Jain S, Srinath MS, Narendra C, Reddy SN, Sindhu A
pp. 342–349 · DOI: 10.4103/0975-1483.71619 · Published
The objective of this study was to evaluate the effect of formulation variables on the release properties, floating lag time, and hardness, when developing floating tablets of Ranitidine hydrochloride, by the statistical…
- Article
Floating Drug Delivery of Nevirapine as a Gastroretentive System
Vedha Hari BN, Brahma Reddy A, Samyuktha Rani B
pp. 350–355 · DOI: 10.4103/0975-1483.71622 · Published
A multiple-unit floating drug delivery system based on gas formation technique was developed, in order to prolong the gastric residence time and to increase the overall bioavailability of the dosage form. The floating be…
- Article
Preparation and Evaluation of Nano-vesicles of Brimonidine Tartrate as an Ocular Drug Delivery System
Prabhu P, Nitish Kumar R, Koland M, Harish NM, Vijayanarayan K, Dhondge G, Charyulu RN
pp. 356–361 · DOI: 10.4103/0975-1483.71623 · Published
The objective of the present investigation was to design a vesicular formulation of brimonidine tartrate and evaluate its ability to reduce the dosing frequency and improve the therapeutic efficacy of the drug. Nanovesic…
Pharmacognosy
- Article
Enhancement of the Norfloxacin Antibiotic Activity by Gaseous Contact with the Essential Oil of Croton zehntneri
Coutinho HDM, Matias EFF, Santos KKA, Tintino SR, Souza CES, Guedes GMM, Santos FAD, Costa JGM, Falcão-Silva VS, Siqueira-Júnior JP
pp. 362–364 · DOI: 10.4103/0975-1483.71625 · Published
This is the first on the modulation of norfloxacin antibiotic activity by the volatile compounds of an essential oil. We report the chemical composition and antibiotic modifying activity of the essential oil extracted fr…
- Article
Free Radical Scavenging and Analgesic Activities of Cucumis sativus L. Fruit Extract
Kumar D, Kumar S, Singh J, Narender N, Rashmi R, Vashistha BD, Singh N
pp. 365–368 · DOI: 10.4103/0975-1483.71627 · Published
The aqueous fruit extract of Cucumis sativus L. was screened for free radical scavenging and analgesic activities. The extract was subjected to in vitro antioxidant studies at 250 and 500 μg/ml and analgesic study at the…
Pharmacology
- Article
Antiulcer and Anti-inflammatory Activity of Aerial Parts Enicostemma littorale Blume
Roy SP, Niranjan CM, Jyothi TM, Shankrayya MM, Vishawanath KM, Prabhu K, Gouda VA, Setty RS
pp. 369–373 · DOI: 10.4103/0975-1483.71629 · Published
The antiulcer and in vitro anti-inflammatory activities of the aerial parts of Enicostemma littorale against aspirin, ethanol, and pyloric ligation-induced ulcers in rats and bovine serum albumin denaturation were studie…
- Article
In Vitro Effects of Albendazole on Raillietina echinobothrida, the Cestode of Chicken, Gallus domesticus
Lalchhandama K
pp. 374–378 · DOI: 10.4103/0975-1483.71630 · Published
Albendazole, a member of benzimidazole group of compounds, has been shown to have a broad spectrum activity against all classes of helminth parasites. Although it has also been experimentally proven to be effective again…
- Article
Modulation of the P-Glycoproein-Mediated Intestinal Secretion of Glibenclamide: In Vitro and In Vivo Assessments
Srirangam P, Vidya Sagar J
pp. 379–383 · DOI: 10.4103/0975-1483.71632 · Published
The everted gut sac method was used to assess the role of the P-glycoprotein (P-gp) on the intestinal secretion of glibenclamide, a prototype of drug used to treat diabetic mellitus. The study included the evaluation of …
- Article
Evaluation of the Hypoglycemic Activity of Cucumis metuliferus (Cucurbitaceae) Fruit Pulp Extract in Normoglycemic and Alloxan- Induced Hyperglycemic Rats
Jimam NS, Wannang NN, Omale S, Gotom B
pp. 384–387 · DOI: 10.4103/0975-1483.71633 · Published
The hypoglycemic effects of the fruit extract of C. metuliferus was investigated in normoglycemic and alloxaninduced hyperglycemic rats. The results showed that there was an insignificant (P > 0.05) decrease in the blood…
Pharm Chemistry
- Article
Comparative Molecular Similarity Indices Analysis of 1-(Naphthylalky1)-1H–imidazole Analogs with Antiepileptic Activity
Ganguly S, Mishra R
pp. 388–393 · DOI: 10.4103/0975-1483.71635 · Published
A three-dimensional quantitative structure-activity relationship (3D QSAR) of 44 structurally and functionally diverse series of 1- (Naphthylalkylimidazoles) as antiepileptic agents was studied using the Comparative mole…
- Article
Synthesis, Characterization, and Biological Evaluation of certain 6-methyl-2(3H)-benzo-1, 3-thiazolyl-1'-ethylidene-2-(o, p- Substituted Acetophenones) Hydrazine Analogs
Alang G, Kaur G, Kaur R, Singh A, Tiwari R
pp. 394–398 · DOI: 10.4103/0975-1483.71636 · Published
In the present study, five new derivatives (GG4 to GG8) of benzothiazoles were synthesized and evaluated against Staphylococcus aureus (MTCC 737), Pseudomonas aeruginosa (MTCC 424), Escherichia coli (MTCC 1687), and yeas…
- Article
Anti-tumor Activity of N4 [(E)-1-(2-hydroxyphenyl) Methylidene], N4-[(E)-2-Phenylethylidene], N4 [(E,2E)-3-Phenyl-2-propenylidene], and N4[(E)ethylidene] Isonicotinohydrazide on K562 and Jurkat Cell Lines
Shabani F, Ghammamy S, Jahazi A, Siavoshifar F
pp. 399–402 · DOI: 10.4103/0975-1483.71638 · Published
Using the water eliminated mechanism, reactions of 4-pyridinecarboxylic acid hydrazide and salicylaldehyde, benzaldehyde, cinnamaldehyde, and formaldehyde afforded the corresponding N4[(E)-1-(2-hydroxyphenyl) methylidene…
Quality Assurance
- Article
Global Medical Device Nomenclature: The Concept for Reducing Device-Related Medical Errors
Anand K, Saini SK, Singh BK, Veermaram C
pp. 403–409 · DOI: 10.4103/0975-1483.71637 · Published
In the medical device field, there are a number of players, having quite different responsibilities and levels of understanding of the processes, but all with one common interest, that of ensuring the availability of sou…
Pharm Analysis
- Article
A Simple RP-HPLC Method for Quantitation of Itopride HCl in Tablet Dosage Form
Thiruvengada Rajan VS, Mohamed Saleem TS, Ramkanth S, Alagusundaram M, Ganaprakash K, Madhusudhana Chetty 3
pp. 410–413 · DOI: 10.4103/0975-1483.71634 · Published
An isocratic reversed phase high-performance liquid chromatographic method with ultraviolet detection at 220 nm has been developed for the quantification of itopride hydrochloride in tablet dosage form. The quantificatio…
- Article
Visible Spectrophotometric Estimation of Diacerein in Bulk and Pharmaceutical Dosage Forms
Sivakumar R, Nallasivan PK, Saranya KC, Sam Solomon WD, Akelesh T, Venkatnarayanan R
pp. 414–416 · DOI: 10.4103/0975-1483.71631 · Published
Two simple, sensitive, accurate, rapid, and economical spectrophotometric methods have been developed for the estimation of diacerein in Pharmaceutical dosage forms. Method A is based on the reaction of diacerein with Fo…
- Article
UV Spectrophotometric Method for Assay of the Anti-Retroviral Agent Lamivudine in Active Pharmaceutical Ingredient and in its Tablet Formulation
Deepali G, Elvis M
pp. 417–419 · DOI: 10.4103/0975-1483.71628 · Published
A rapid, simple, accurate, and economical spectrophotometric method has been developed and validated for the assay of the anti-retroviral agent lamivudine in active pharmaceutical ingredients (API) and in its tablet form…
- Article
Zero Order Spectrophotometric Method for Estimation of Escitalopram Oxalate in Tablet Formulations
Sharma S, Rajpurohit H, Sonwal C, Bhandari A, Choudhary VR, Jain T
pp. 420–423 · DOI: 10.4103/0975-1483.71626 · Published
A new, simple, fast and reliable zero order spectrophotometric method has been developed for determination of Escitalopram Oxalate in bulk and tablet dosage forms. The quantitative determination of drug was carried out u…
Clinical Pharmacy
- Article
A Study on Drug-Drug Interaction of Esomeprazole and Anti-Diabetic Drugs
Swamy VKM, Setty RS, Shankaraiah MM, Jyothi TM, Rajendra SV
pp. 424–427 · DOI: 10.4103/0975-1483.71624 · Published
Drug–drug interaction between esomeprazole at therapeutic and higher doses and sulfonylureas was studied. Sulfonylureas (tolbutamide 40 mg/kg and glibenclamide 40 μg/kg) were administered and the time to onset of hypogly…
General Pharmacy
- Article
Revisiting Metformin: Annual Vitamin B12 Supplementation may become Mandatory with Long-Term Metformin Use
Mahajan R, Gupta K
pp. 428–429 · DOI: 10.4103/0975-1483.71621 · Published
Monitoring of adverse drug reactions of a drug is a continuous process and runs through-out the life of a drug. Many rare adverse effects of a drug are documented after years of use; when a single case (signal generation…
Letter to Editor
- Article
Dronedarone: A New Therapeutic Alternative for Cardiac Arrhythmias
Upaganlawar A, Gandhi H, Balaraman R
pp. 430 · DOI: 10.4103/0975-1483.71620 · Published
Sir, As a new therapeutic agent for cardiac arrhythmias, dronedarone (Multaq®), a drug from Sanofi-Aventis, was approved by the FDA on July 2, 2009.[1] It is now available in the market in the form of tablets having 400 …
Title Index
- Article
Title Index, 2010
Patel MS
pp. 435–436 · DOI: · Published
Title Index, 2010