Visible Spectrophotometric Estimation of Diacerein in Bulk and Pharmaceutical Dosage Forms
Sivakumar R1★, Nallasivan PK1, Saranya KC1, Sam Solomon WD1, Akelesh T1, Venkatnarayanan R1★ Corresponding author
- 1Department of Pharmaceutical Analysis, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore-641402, Tamil Nadu, INDIA.
CORRESPONDENCE
Sivakumar R
Department of Pharmaceutical Analysis, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore-641402, Tamil Nadu, INDIA.
Volume 2, Issue 4 · pp. 414–416 · PUBLISHED · DOI: 10.4103/0975-1483.71631
ABSTRACT
Two simple, sensitive, accurate, rapid, and economical spectrophotometric methods have been developed for the estimation of diacerein in Pharmaceutical dosage forms. Method A is based on the reaction of diacerein with Folin-Ciocalteu reagent, in the presence of 0.5 N sodium hydroxide solution, giving a pink-colored chromogen, which shows maximum absorbance at 512 nm against reagent blank, while method B is based on the oxidation of diacerein with potassium permanganate in an alkaline medium giving a pink-colored chromogen, which shows maximum absorption at 497.5 nm. Beer's law was obeyed in the concentration range of 4 – 20 μg/ml for both methods A and B. Results of the analysis were validated statistically, and by recovery studies.
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R, S., PK, N., KC, S., WD, S. S., T, A., & R, V. (). Visible Spectrophotometric Estimation of Diacerein in Bulk and Pharmaceutical Dosage Forms. Journal of Young Pharmacists, 2(4), 414–416. https://doi.org/10.4103/0975-1483.71631