Antiulcer and Anti-inflammatory Activity of Aerial Parts Enicostemma littorale Blume
Roy SP1, Niranjan CM1, Jyothi TM1, Shankrayya MM1, Vishawanath KM1, Prabhu K1, Gouda VA1, Setty RS2★★ Corresponding author
- 1Department of Pharmacology, S. C. S. College of Pharmacy, Harapanahalli - 583131, Karnataka, INDIA.
- 2College of Clinical Pharmacy, King Faisal University, Al Ahsa, KINGDOM OF SAUDI ARABIA.
CORRESPONDENCE
Setty RS
College of Clinical Pharmacy, King Faisal University, Al Ahsa, KINGDOM OF SAUDI ARABIA.
Volume 2, Issue 4 · pp. 369–373 · PUBLISHED · DOI: 10.4103/0975-1483.71629
ABSTRACT
The antiulcer and in vitro anti-inflammatory activities of the aerial parts of Enicostemma littorale against aspirin, ethanol, and pyloric ligation-induced ulcers in rats and bovine serum albumin denaturation were studied. The extract (200 mg/kg and 400 mg/kg po) was administered to the overnight fasted rats, one hour prior to aspirin / alcohol / pyloric ligation challenge. The ulcer index, tissue GSH levels, and lipid peroxidation levels were estimated in all the models of ulcers and the volume of gastric secretion, acidity, and pH, were estimated in the pyloric ligation model of ulcers. Pretreatment with the extract showed a dose-dependent decrease in the ulcer index (Against Aspirin, ethanol challenge, and pyloric ligation. The prior administration of the extract also reduced the total acidity, free acidity, and volume of gastric secretion, and elevated the gastric pH. In addition, it was also observed that the extract inhibited the serum albumin denaturation in a dose-dependent manner. It may be concluded that the methanolic extract possesses antiulcer activity, and the anti-inflammatory activity of the extract may be attributed to the antioxidant potential, as reported earlier.
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SP, R., CM, N., TM, J., MM, S., KM, V., K, P., VA, G., & RS, S. (). Antiulcer and Anti-inflammatory Activity of Aerial Parts Enicostemma littorale Blume. Journal of Young Pharmacists, 2(4), 369–373. https://doi.org/10.4103/0975-1483.71629