Antiurolithiatic Activity of Whole-Plant Hydroalcoholic Extract of Pergularia daemia in Rats

ABSTRACT

The whole-plant, Pergularia daemia (Family: Asclepediaceae), extract (50% alcohol) was investigated for its antiurolithiatic and diuretic activity. Ethylene glycol (0.75% in water) feeding resulted in hyperoxaluria as well as increased renal excretion of calcium and phosphate. Alcoholic extract (400 mg/kg) of P. daemia was given orally in curative and preventive regimens over a period of 28 days. Supplementation with extract significantly (P < 0.001) lowered the urinary excretion and kidney retention levels of oxalate, calcium and phosphate. Furthermore, high serum levels of urea nitrogen, creatinine and uric acid were significantly (P < 0.001) reduced by the extract. The results were comparable with the standard drug, cystone (750 mg/kg). The reduction of stoneforming constituents in urine and their decreased kidney retention reduces the solubility product of crystallizing salts such as calcium oxalate and calcium phosphate, which could contribute to the antiurolithiatic property of the extract. The extract exhibited significant diuretic activity at dose of 400 mg/kg body weight as evidenced by increased total urine volume and the urine concentration of Na+, and K+. These findings affirm assertions made regarding the effectiveness of the extract of this plant against urinary pathologies in the Indian folk medicine.

KEYWORDS

• Diuretic activity
• ethylene glycol
• hyperoxaluria
• Lipid peroxidation
• urolithiasis

Showing references and in-text citations exactly as published.

• DOI10.4103/0975-1483.76417Copy

RELATED ARTICLES

Matched on section and article type within this issue of JYP.

• Article · VOLUME 3, ISSUE 1Effects of Cynodon dactylon on Stress-Induced Infertility in Male RatsChidrawar VR, Chitme HR, Patel KN, Patel NJ, Racharla VR, Dhoraji NC, Vadalia KR · pp. 26–35PharmacognosySame type: Article
• Article · VOLUME 3, ISSUE 1Design and Evaluation of Self-Nanoemulsifying Drug Delivery System of FlutamideJeevana Jyothi B, Sreelakshmi K · pp. 4–8Same type: Article
• Article · VOLUME 3, ISSUE 1Biodegradable Chitosan-Based Ambroxol Hydrochloride Microspheres: Effect of Cross-Linking AgentsGangurde HH, Chavan NV, Mundada AS, Derle DV, Tamizharasi S · pp. 9–14Same type: Article
• Article · VOLUME 3, ISSUE 1Six Sigma: Process of Understanding the Control and Capability of Ranitidine Hydrochloride TabletChabukswar AR, Jagdale SC, Kuchekar BS, Joshi VD, Deshmukh GR, Kothawade HS, Kuckekar AB, Lokhande PD · pp. 15–25Same type: Article