Article · Volume 3, Issue 4 · pp. 310–314

Synthesis, Characterization and Biological Activity Studies of 1,3,4-Oxadiazole Analogs

Bhat KI¹, Sufeera K¹, Chaitanya Sunil Kumar P¹

¹Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, Nitte University, Deralakatte, Mangalore, Karnataka, INDIA.

Abstract

The reaction of p-bromoanilino acetohydrazide(II) with aromatic aldehydes in alcohol yielded 2-[4-bromo aniline] N-substituted benzylidine hydrazides (IIIa-IIIj), which in presence of yellow mercuric oxide and iodine in DMF, yielded corresponding 4-bromo[(N-5-substituted 1,3,4 oxadiazole-2-yl)methyl]aniline (IVa-IVj). Structures of the compounds synthesized were confirmed by IR, ^1HNMR and MASS spectroscopic analysis. The newly synthesized compounds were screened for antibacterial, antifungal and anti-inflammatory activities. Some of the compounds showed remarkable antibacterial, antifungal and anti-inflammatory activities.

Keywords: 1; 3; 4-Oxadiazoles; antibacterial activity; antifungal activity; anti-inflammatory activity

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