Synthesis, Characterization and Biological Activity Studies of 1,3,4-Oxadiazole Analogs
Bhat KI1★, Sufeera K1, Chaitanya Sunil Kumar P1★ Corresponding author
- 1Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, Nitte University, Deralakatte, Mangalore, Karnataka, INDIA.
CORRESPONDENCE
Bhat KI
Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, Nitte University, Deralakatte, Mangalore, Karnataka, INDIA.
Volume 3, Issue 4 · pp. 310–314 · PUBLISHED · DOI: 10.4103/0975-1483.90243
ABSTRACT
The reaction of p-bromoanilino acetohydrazide(II) with aromatic aldehydes in alcohol yielded 2-[4-bromo aniline] N-substituted benzylidine hydrazides (IIIa-IIIj), which in presence of yellow mercuric oxide and iodine in DMF, yielded corresponding 4-bromo[(N-5-substituted 1,3,4 oxadiazole-2-yl)methyl]aniline (IVa-IVj). Structures of the compounds synthesized were confirmed by IR, ^1HNMR and MASS spectroscopic analysis. The newly synthesized compounds were screened for antibacterial, antifungal and anti-inflammatory activities. Some of the compounds showed remarkable antibacterial, antifungal and anti-inflammatory activities.
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KI, B., K, S., & P, C. S. K. (). Synthesis, Characterization and Biological Activity Studies of 1,3,4-Oxadiazole Analogs. Journal of Young Pharmacists, 3(4), 310–314. https://doi.org/10.4103/0975-1483.90243