Oxidative Stress Induced by Fluoroquinolones on Treatment for Complicated Urinary Tract Infections in Indian Patients
Talla V1, Veerareddy PR2★★ Corresponding author
- 1Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, INDIA.
- 2Department of Pharmaceutics, St Peters’ Institute of Pharmaceutical Sciences, Warangal, Andhra Pradesh, INDIA.
CORRESPONDENCE
Veerareddy PR
Department of Pharmaceutics, St Peters’ Institute of Pharmaceutical Sciences, Warangal, Andhra Pradesh, INDIA.
Volume 3, Issue 4 · pp. 304–309 · PUBLISHED · DOI: 10.4103/0975-1483.90242
ABSTRACT
The aim of the study is to examine the oxidative stress in patients on fluoroquinolones (ciprofloxacin, levofloxacin, gatifloxacin) therapy for complicated urinary tract infections and to correlate with plasma concentrations at different time intervals. Superoxide dismutase (SOD), glutathione, plasma antioxidant status and lipid peroxides were evaluated in 52 patients on different dosage regimens up to 5 days. There is significant and gradual elevation of lipid peroxide levels in patients on ciprofloxacin (3.6±0.34 nmol/ml to 6.2±0.94 nmol/ml) and levofloxacin (3.5±0.84 nmol/ml to 5.1±0.28 nmol/ml) dosage regimen but not with gatifloxacin (3.5±0.84 nmol/ml to 3.74±0.17 nmol.ml). There was substantial depletion in both SOD and glutathione levels particularly with ciprofloxacin. On the 5th day of treatment, plasma antioxidant status decreased by 77.6%, 50.5%, 7.56% for ciprofloxacin, levofloxacin and gatifloxacin respectively. In conclusion ciprofloxacin and levofloxacin induce more reactive oxygen species that lead to cell damage than gatifloxacin irrespective of their concentrations in patient population.
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V, T., & PR, V. (). Oxidative Stress Induced by Fluoroquinolones on Treatment for Complicated Urinary Tract Infections in Indian Patients. Journal of Young Pharmacists, 3(4), 304–309. https://doi.org/10.4103/0975-1483.90242