Volume 3, Issue 4

· pp. 259–350 · 15 articles

In this issue

Article
Formulation and Evaluation of Cephalexin Extended Release Matrix Tablets Using 32 Factorial Design
Jishnu V, Prabhakaran R, Gilhotra RM
pp. 259–266 · DOI: 10.4103/0975-1483.90233 · Published
The aim of the present investigation was to prepare extended release film coated matrix tablets of cephalexin using binary mixture of two grades of hydrophilic polymer, hydroxypropyl methyl cellulose (HPMC), by direct co…
Article
Preparation and Characterization of Pioglitazone Cyclodextrin Inclusion Complexes
Pandit V, Gorantla R, Devi K, Pai RS, Sarasija S
pp. 267–274 · DOI: 10.4103/0975-1483.90234 · Published
Pioglitazone, a class II Biopharmaceutical Classification System drug having poor water solubility and slow dissolution rate may have a negative impact on its subtherapeutic plasma drug levels leading to therapeutic fail…
Article
Formulation and Optimization of Mucoadhesive Nanodrug Delivery System of Acyclovir
Bhosale UV, Kusum Devi V, Jain N
pp. 275–283 · DOI: 10.4103/0975-1483.90236 · Published
Acyclovir is an antiviral drug used for the treatment of herpes simplex virus infections, with an oral bioavailability of only 10-20% [limiting absorption in gastrointestinal tract to duodenum and jejunum] and half-life …

Article
Antimicrobial Activity of the Extract of Stem Bark of Diplotropis Ferruginea Benth
Cerqueira GS, Rocha NFM, Almeida JRGS, de Freitas APF, Lima EO, Filho JMB, de Freitas RM, Melo Diniz MFF
pp. 284–286 · DOI: 10.4103/0975-1483.90237 · Published
This is the first report about the antibacterial activity of Diplotropis ferrugineaBenth. In this study, the ethanol extract of D. ferrugineawas tested for its antimicrobial activity against strains gram-positive and gra…

Article
Litsea Deccanensis Ameliorates Myocardial Infarction in Wistar Rats: Evidence from Biochemical and Histological Studies
Bharath Kumar P, Darlin Quine S, Mari Kannan M
pp. 287–296 · DOI: 10.4103/0975-1483.90239 · Published
The present study was designed to evaluate the cardioprotective effects of methanolic extract of Litsea deccanensis (MELD) against isoproterenol-induced myocardial infarction in rats by studying cardiac markers, lipid pe…
Article
Cardioprotective Effects of Lagenaria siceraria Fruit Juice on Isoproterenol-induced Myocardial Infarction in Wistar Rats: A Biochemical and Histoarchitecture Study
Upaganlawar A, Balaraman R
pp. 297–303 · DOI: 10.4103/0975-1483.90241 · Published
The present study was designed to evaluate the cardioprotective effects of Lagenaria siceraria fruit juice in isoproterenol-induced myocardial infarction. Rats injected with isoproterenol (200 mg/kg, s.c.) showed a signi…
Article
Oxidative Stress Induced by Fluoroquinolones on Treatment for Complicated Urinary Tract Infections in Indian Patients
Talla V, Veerareddy PR
pp. 304–309 · DOI: 10.4103/0975-1483.90242 · Published
The aim of the study is to examine the oxidative stress in patients on fluoroquinolones (ciprofloxacin, levofloxacin, gatifloxacin) therapy for complicated urinary tract infections and to correlate with plasma concentrat…

Article
Synthesis, Characterization and Biological Activity Studies of 1,3,4-Oxadiazole Analogs
Bhat KI, Sufeera K, Chaitanya Sunil Kumar P
pp. 310–314 · DOI: 10.4103/0975-1483.90243 · Published
The reaction of p-bromoanilino acetohydrazide(II) with aromatic aldehydes in alcohol yielded 2-[4-bromo aniline] N-substituted benzylidine hydrazides (IIIa-IIIj), which in presence of yellow mercuric oxide and iodine in …

Article
High Performance Liquid Chromatographic Fluorescence 'HWHFWLRQ0HWKRGIRUWKH4XDQWL¿FDWLRQRI5LYDVWLJPLQHLQ5DW Plasma and Brain: Application to Preclinical Pharmacokinetic Studies in Rats
Arumugam K, Chamallamudi MR, Mallayasamy SR, Mullangi R, Ganesan S, Jamadar L, Ranjithkumar A, Udupa N
pp. 315–321 · DOI: 10.4103/0975-1483.90244 · Published
A highly sensitive and selective high performance liquid chromatographic fluorescence detection method has been developed and validated for the quantification of rivastigmine in rat plasma and brain. Protein precipitatio…

Article
Pharmacokinetic Evaluation of Paclitaxel in South Indian Cancer Patients: A Prospective Study
Vasantha J, Kannan G, Goud T, Palani T, Vanitha R, Anitha R, Priya JJM
pp. 322–329 · DOI: 10.4103/0975-1483.90245 · Published
Paclitaxel is a promising drug in the treatment of different solid tumors. It exhibits nonlinear pharmacokinetics, particularly when administered as a constant rate infusion for shorter duration (e.g., 3 h). Because of t…
Article
Drug–drug Interactions in Hospitalized Cardiac Patients
Mateti UV, Rajakannan T, Nekkanti H, Rajesh V, Mallaysamy SR, Ramachandran P
pp. 329–333 · DOI: 10.4103/0975-1483.90246 · Published
Drug–drug interactions (DDIs) are defined as two or more drugs interacting in such a manner that the effectiveness or toxicity of one or more drugs is altered. DDI in patients receiving multidrug therapy is a major conce…

Article
Pharmacy Education in India: Strategies for a Better Future
Jishnu V, Gilhotra RM, Mishra DN
pp. 334–342 · DOI: 10.4103/0975-1483.90248 · Published
In this world of specialization and globalization the pharmacy education in India is suffering from serious backdrops and flaws. There is an urgent need to initiate an academic exercise aimed at attaining revamping of cu…

Article
Buyouts of Indian Pharmaceutical Companies by Multinational Pharmaceutical Companies: An Issue of Concern
Sreedhar D, Janodia MD, Ligade VS
pp. 343–344 · DOI: 10.4103/0975-1483.90250 · Published
Sir, Indian pharmaceutical industry has climbed the ladder to reach third position in terms of volume and fourteenth position in value terms. It is estimated to be worth US$ 4.5 billion at annual growth rate of 8–9%. Ind…

Article
Author Index, 2011
Devi AK
pp. 345–348 · DOI: · Published
Adamu AK see Ahmed TS et al., Ahirwar D see Hade D et al. Ahmed TS, Magaji MG, Yaro AH, Musa AM, Adamu AK. Aqueous methanol extracts of Cochlospermum tinctorium (A. Rich) possess analgesic and anti-inflammatory activitie…

Article
Title Index, 2011
Pooja Sharma
pp. 349–350 · DOI: · Published
A perspective for clinical pharmacy curriculum development and validation in Asian developing nations.