Cardioprotective Effects of Lagenaria siceraria Fruit Juice on Isoproterenol-induced Myocardial Infarction in Wistar Rats: A Biochemical and Histoarchitecture Study
Upaganlawar A1★, Balaraman R1★ Corresponding author
- 1Pharmacy Department, Faculty of Technology and Engineering, The M. S. University of Baroda, Vadodara, Gujarat, INDIA.
CORRESPONDENCE
Upaganlawar A
Pharmacy Department, Faculty of Technology and Engineering, The M. S. University of Baroda, Vadodara, Gujarat, INDIA.
Volume 3, Issue 4 · pp. 297–303 · PUBLISHED · DOI: 10.4103/0975-1483.90241
ABSTRACT
The present study was designed to evaluate the cardioprotective effects of Lagenaria siceraria fruit juice in isoproterenol-induced myocardial infarction. Rats injected with isoproterenol (200 mg/kg, s.c.) showed a significant increase in the levels of serum uric acid, tissue Na and Ca** ions and membrane-bound Caand mg*2-ATPase activity. A significant decrease in the levels of serum protein, tissue K ion, vitamin E level, and the activities of Na+/K+-ATPase and mg*2-ATPase was observed. Isoproterenol injected rats also showed a significant increase in the intensity of lactate dehydrogenase isoenzyme and histopathologic alterations in the heart. Treatment with L. siceraria fruit juice (400 mg/kg/day, p.o.) for 30 days and administration of isoproterenol on 29th and 30th days showed a protective effect on altered biochemical and histopathologic changes. These findings indicate the cardioprotective effect of L. siceraria fruit juice in isoproterenol-induced myocardial infarction in rats.
KEYWORDS
REFERENCES
As publishedShowing references and in-text citations exactly as published.
Cite this article
SELECT FORMAT
A, U., & R, B. (). Cardioprotective Effects of Lagenaria siceraria Fruit Juice on Isoproterenol-induced Myocardial Infarction in Wistar Rats: A Biochemical and Histoarchitecture Study. Journal of Young Pharmacists, 3(4), 297–303. https://doi.org/10.4103/0975-1483.90241