Article · Volume 4, Issue 1 · pp. 33–37

Design and Microwave-assisted Synthesis of 1,3,4-Oxadiazole Derivatives for Analgesic and Anti-inflammatory Activity

Biju CR^1,4, Ilango K², Manju Prathap³

¹Department of Pharmaceutical Chemistry, Devaki Amma Memorial College of Pharmacy, Malappuram, Kerala, INDIA.
²SRM College of Pharmacy, SRM University, Kancheepuram, Chennai, Tamil Nadu, INDIA.
³Department of Pharmaceutical Chemistry, Amrutha Institute of Medical Sciences, Cochin, Kerala, INDIA.
⁴Karpagam University, Echanari, Coimbatore, Tamil Nadu, INDIA.

Abstract

1,3,4-Oxadiazoles form a biologically important group of compounds having activities like analgesic, anti-inflammatory, bactericidal, antifungal, anticonvulsant, psychotropic, plant growth regulating and mono amine oxidase inhibition. This research has focused on the incorporation of the oxadiazole moiety into isoniazid because of their versatile biological action, to get 2-aryl-5-(4-pyridyl)-1,3,4-oxadiazole to explore the possibilities of some altered biological action. 1,3,4-Oxadiazole derivatives were synthesized by microwave-assisted synthesis and screened for their analgesic and anti-inflammatory activities. The synthesized compounds were characterized by melting point, thin layer chromatography, infrared spectroscopy, nuclear magnetic resonance spectroscopy, etc. Almost all the synthesized compounds possessed good activity as compared to the standard.

Keywords: 1; 3; 4-Oxadiazole; analgesic; anti-inflammatory; isoniazid

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