Design and Microwave-assisted Synthesis of 1,3,4-Oxadiazole Derivatives for Analgesic and Anti-inflammatory Activity
Biju CR1,4★, Ilango K2, Manju Prathap3★ Corresponding author
- 1Department of Pharmaceutical Chemistry, Devaki Amma Memorial College of Pharmacy, Malappuram, Kerala, INDIA.
- 2SRM College of Pharmacy, SRM University, Kancheepuram, Chennai, Tamil Nadu, INDIA.
- 3Department of Pharmaceutical Chemistry, Amrutha Institute of Medical Sciences, Cochin, Kerala, INDIA.
- 4Karpagam University, Echanari, Coimbatore, Tamil Nadu, INDIA.
CORRESPONDENCE
Biju CR
Department of Pharmaceutical Chemistry, Devaki Amma Memorial College of Pharmacy, Malappuram, Kerala, INDIA.
Volume 4, Issue 1 · pp. 33–37 · PUBLISHED · DOI: 10.4103/0975-1483.93578
ABSTRACT
1,3,4-Oxadiazoles form a biologically important group of compounds having activities like analgesic, anti-inflammatory, bactericidal, antifungal, anticonvulsant, psychotropic, plant growth regulating and mono amine oxidase inhibition. This research has focused on the incorporation of the oxadiazole moiety into isoniazid because of their versatile biological action, to get 2-aryl-5-(4-pyridyl)-1,3,4-oxadiazole to explore the possibilities of some altered biological action. 1,3,4-Oxadiazole derivatives were synthesized by microwave-assisted synthesis and screened for their analgesic and anti-inflammatory activities. The synthesized compounds were characterized by melting point, thin layer chromatography, infrared spectroscopy, nuclear magnetic resonance spectroscopy, etc. Almost all the synthesized compounds possessed good activity as compared to the standard.
KEYWORDS
REFERENCES
As publishedShowing references and in-text citations exactly as published.
Cite this article
SELECT FORMAT
CR, B., K, I., & Prathap, M. (). Design and Microwave-assisted Synthesis of 1,3,4-Oxadiazole Derivatives for Analgesic and Anti-inflammatory Activity. Journal of Young Pharmacists, 4(1), 33–37. https://doi.org/10.4103/0975-1483.93578