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Journal of Young PharmacistsNOW IN
Article

Formulation Development and Evaluation of Alginate Microspheres of Ibuprofen

Nagpal M1★, Maheshwari DK2, Rakha P3, Dureja H4, Goyal S5, DhingraDhingra G6★ Corresponding author

  1. 1Department of Pharmaceutics, College of Pharmacy, Chitkara University, Patiala, Punjab, INDIA.
  2. 2Pharmaceutics, INDIA.
  3. 3Pharmacology, Rajendra Institute of Technology and Sciences, Sirsa, Haryana, INDIA.
  4. 4Pharmaceutics, M. D. University, Rohtak, INDIA.
  5. 5Pharmaceutical Chemistry, Malwa College of Pharmacy, Bhatinda, Punjab, INDIA.
  6. 6Pharmaceutics, NCRD Sterling Institute of Pharmacy, Nerul, Navi Mumbai, Maharashtra, INDIA.

CORRESPONDENCE

Nagpal M

Department of Pharmaceutics, College of Pharmacy, Chitkara University, Patiala, Punjab, INDIA.

nagpalmanju@ymail.com

Volume 4, Issue 1 · pp. 13–16 · PUBLISHED · DOI: 10.4103/0975-1483.93573

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ABSTRACT

The present study was designed to investigate the effects of different variables on the release profile of ibuprofen microspheres formulated using modified emulsification method. Eight batches of microspheres (F1–F8) were prepared by applying 2³ factorial design. The amount of sodium alginate, amount of calcium chloride, and amount of magnesium stearate were selected as formulation variables. All the batches were evaluated in terms of percentage yield, percentage encapsulation efficiency and in vitro release characteristics. The batch F7 was found to be optimum batch and was further characterized via scanning electron microscopy (SEM) and particle size analysis. Multiple linear regression was applied to confirm significant effect of each variable on release characteristics. The model developed in the present study can be effectively utilized to achieve the formulation with desired release characteristics.

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    M, N., DK, M., P, R., H, D., S, G., & G, D. (). Formulation Development and Evaluation of Alginate Microspheres of Ibuprofen. Journal of Young Pharmacists, 4(1), 13–16. https://doi.org/10.4103/0975-1483.93573