A Novel Extraction Method and Some Physicochemical Properties of Extractives of Irvingia Gabonensis Seeds
Ogaji IJ1, Nan A2, Hoag SW2★★ Corresponding author
- 1Departments of Pharmaceutical Technology, University of Jos, Jos, Plateau State, NIGERIA.
- 2Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD, USA.
CORRESPONDENCE
Hoag SW
Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD, USA.
Volume 4, Issue 2 · pp. 66–72 · PUBLISHED · DOI: 10.4103/0975-1483.96612
ABSTRACT
The plant Irvingia gabonensis contains lipids and polymer extractives that can be a good source of excipients for oral pharmaceutical formulations. These constituents are usually extracted from the seeds with the aid of either organic solvents or enzymes. The purpose of this paper was to describe a novel, simpler, cheaper, and safer method for the simultaneous extraction of lipids and gum from I. gabonensis. A 100.0 g of seeds of I. gabonensis in 200 mL deionized water was heated at 78°C in the presence of 2.0 g sodium chloride for 1 h, and the mixture was allowed to stand for the lipids to be separated and removed by filtration. The samples were air dried at 25-30°C. The liquid fraction was centrifuged at 3445 rpm for 30 min, and the supernatant portion containing the gum was freeze dried. The samples were investigated for their true, bulk, and tapped densities as well as particle size and particle size distributions. The rheological, and near infrared absorption spectra as well as thermal behavior of the samples were also studied. The lipid and the polymeric components of I. gabonensis seeds were successfully extracted simultaneously. The true densities of the fatty and gum components were, respectively, 1.000 and 1.544 g/cm³. The melting point of the fat was 40°C and T, of the gum was 232°C. These values were similar to those described in the literature for the components using the traditional method, demonstrating the effectiveness and efficiency of this simple novel method.
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IJ, O., A, N., & SW, H. (). A Novel Extraction Method and Some Physicochemical Properties of Extractives of Irvingia Gabonensis Seeds. Journal of Young Pharmacists, 4(2), 66–72. https://doi.org/10.4103/0975-1483.96612