Anti-diabetic activities of (part) and fractions of Stereospermum tetragonum DC
Renjit Bino Kingsley1, Manisha Mishra2, Pemaiah Brindha2, Appian Subramoniam1★★ Corresponding author
- 1Division of Phytochemistry and Phytopharmacology, Tropical Botanic Garden and Research Institute, Palode, Thiruvananthapuram 695562, INDIA.
- 2Department of Ayurvedic Research, Sastra University, Tanjore, INDIA.
CORRESPONDENCE
Appian Subramoniam
Division of Phytochemistry and Phytopharmacology, Tropical Botanic Garden and Research Institute, Palode, Thiruvananthapuram 695562, INDIA.
Received: 11-04-2012; Revised: 12-05-2012; Accepted: 01-09-2012.
Volume 5, Issue 1 · pp. 7–12 · PUBLISHED · DOI: 10.1016/j.jyp.2012.09.002
ABSTRACT
Objectives:To identify the active principles, determine the anti-diabetes activity of fraction of Stereospermum tetragonum root. Materials and Methods: The efficacy was evaluated in streptozotocin induced type 2 diabetic rats and the anti-hyperglycemic activity was studied by glucose tolerance test. The major active compounds were isolated by solvent fractionation and chromatographic techniques and characterized with spectral data. Results:The active fraction of S. tetragonum showed presence of anti-diabetes mellitus activity in type-2 diabetic rats. It did not significantly influence insulin release from cultured islets. Two active principles (active at 2 mg/kg dose) were isolated and characterized with spectral data.One of themwas identified as an iridoid type glycoside and the other one was a lapachol like compound (derivative of naphthoquinone). Conclusions:Two active principles from the anti-diabetes fraction of S. tetragonum root were isolated and identified as an iridoid glycoside and a naphthoquinone derivative.
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Kingsley, R. B., Mishra, M., Brindha, P., & Subramoniam, A. (). Anti-diabetic activities of (part) and fractions of Stereospermum tetragonum DC. Journal of Young Pharmacists, 5(1), 7–12. https://doi.org/10.1016/j.jyp.2012.09.002