Article · Volume 5, Issue 1 · pp. 7–12
Anti-diabetic activities of (part) and fractions of Stereospermum tetragonum DC
Renjit Bino Kingsley1, Manisha Mishra2, Pemaiah Brindha2, Appian Subramoniam1
- 1Division of Phytochemistry and Phytopharmacology, Tropical Botanic Garden and Research Institute, Palode, Thiruvananthapuram 695562, INDIA.
- 2Department of Ayurvedic Research, Sastra University, Tanjore, INDIA.
Abstract
Objectives: To identify the active principles, determine the anti-diabetes activity of fraction of Stereospermum tetragonum root.Materials and Methods: The efficacy was evaluated in streptozotocin induced type 2 diabetic rats and the anti-hyperglycemic activity was studied by glucose tolerance test. The major active compounds were isolated by solvent fractionation and chromatographic techniques and characterized with spectral data.Results: The active fraction of S. tetragonum showed presence of anti-diabetes mellitus activity in type-2 diabetic rats. It did not significantly influence insulin release from cultured islets. Two active principles (active at 2 mg/kg dose) were isolated and characterized with spectral data.One of themwas identified as an iridoid type glycoside and the other one was a lapachol like compound (derivative of naphthoquinone).Conclusions: Two active principles from the anti-diabetes fraction of S. tetragonum root were isolated and identified as an iridoid glycoside and a naphthoquinone derivative.
Keywords: Iridoid glycoside; Naphthoquinone derivative; Stereospermum tetragonum; Anti-diabetes mellitus
The full text of this article is available as a PDF. Open the PDF.