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Article

Antinociceptive activity of the ethanolic extract from barks and leaves of Cnidoscolus quercifolius (Euphorbiaceae) in mice

Leandra Macedo de Araújo Gomes1, Sarah Raquel Gomes de Lima-Saraiva2, Thayne Mayra Dantas de Andrade1, Juliane Cabral Silva1, Tâmara Coimbra Diniz1, Viviane Nunes Sousa Barreto1, Rosemairy Luciane Mendes1, Lucindo José Quintans-Júnior3, Jullyana Siqueira de Sousa Quintans2, Julianeli Tolentino de Lima1, Jackson Roberto Guedes da Silva Almeida1★★ Corresponding author

  1. 1Center for Studies and Research of Medicinal Plants (NEPLAME), Federal University of San Francisco Valley, 56.304-205, Petrolina, Pernambuco, BRAZIL.
  2. 2Federal University of Pernambuco, Department of Pharmacy, 50.670-901, Recife, Pernambuco, BRAZIL.
  3. 3Federal University of Sergipe, Department of Phisiology, 49.100-000, São Cristóvão, Sergipe, BRAZIL.

CORRESPONDENCE

Jackson Roberto Guedes da Silva Almeida

Center for Studies and Research of Medicinal Plants (NEPLAME), Federal University of San Francisco Valley, 56.304-205, Petrolina, Pernambuco, BRAZIL.

jackson.guedes@univasf.edu.br

Volume 6, Issue 2 · pp. 64–69 · PUBLISHED · DOI: 10.5530/jyp.2014.2.10

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ABSTRACT

Cnidoscolus quercifolius is a species native to the Brazilian Caatinga (semi-arid vegetation) popularly known as “favela” and “faveleira” and used in folk medicine to treat pain. The objective of this work was to evaluate the antinociceptive effect of the ethanolic extract from barks (Cqb-EtOH) and leaves (Cql-EtOH) of C. quercifolius in mice using experimental models of nociception. The antinociceptive activity was evaluated by writhing, hot plate and formalin tests. In addition, the rota-rod test was used to evaluate motor coordination. In the acetic acid-induced writhing test, the Cqb-EtOH (100, 200 and 400 mg/kg, i.p.) reduced the number of writhing by 83.70, 81.40 and 88.10%, respectively, while Cql-EtOH reduced by 71.30, 79.40, and 98.70%, respectively. In the formalin test, the extracts reduced the paw licking time in the fi rst and second phases, but the best results were observed in the second phase (infl ammatory pain), reducing by 66.08, 78.26 and 73.97%, as well as 60.11, 75.58, and 79.46% for Cqb-EtOH and Cql-EtOH, respectively. In the hot plate test, the extracts increased the reaction time when compared to control only at dose of 400 mg/kg. Using the rota-rod test, mice treated did not demonstrate any signifi cant motor performance changes. It can be concluded that Cqb-EtOH and Cql-EtOH of C. quercifolius have antinociceptive activity, which supports the popular use of this plant to treat pain.

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    Gomes, L. M. D. A., Lima-Saraiva, S. R. G. D., Andrade, T. M. D. D., Silva, J. C., Diniz, T. C., Barreto, V. N. S., Mendes, R. L., Quintans-Júnior, L. J., Quintans, J. S. D. S., Lima, J. T. D., & Almeida, J. R. G. D. S. (). Antinociceptive activity of the ethanolic extract from barks and leaves of Cnidoscolus quercifolius (Euphorbiaceae) in mice. Journal of Young Pharmacists, 6(2), 64–69. https://doi.org/10.5530/jyp.2014.2.10