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Article

Anticonvulsant activity of quinine in rat models of seizure in comparison with valproate and phenytoin

BN Vallish1★, Shyamal R Sinha2, Abhijeet D Joshi2, Avinash V Turankar3, Sadiq B Patel2, Raj Kishore Mahato1★ Corresponding author

  1. 1Department of Pharmacology, Velammal Medical College Hospital & Research Institute, Madurai, Tamil Nadu, INDIA.
  2. 2Department of Pharmacology, Grant Government Medical College & Sir JJ Group of Hospitals, Mumbai, Maharashtra, INDIA.
  3. 3Department of Pharmacology, Government Medical College, Nagpur, Maharashtra, INDIA.

CORRESPONDENCE

BN Vallish

Department of Pharmacology, Velammal Medical College Hospital & Research Institute, Madurai, Tamil Nadu, INDIA.

vallish.bn@gmail.com

Volume 6, Issue 3 · pp. 32–36 · PUBLISHED · DOI: 10.5530/jyp.2014.3.6

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ABSTRACT

Background: Presently available anti-seizure drugs cannot control seizures in 20-40% epilepsy patients who develop refractory epilepsy. None of the currently available anti-seizure drugs targets hypersynchronization of epileptogenic impulses. Process of hypersynchronization involves gap junction (GJ) activity. Quinine blocks GJs, and prevents seizures in animal models. Since comparative studies were lacking, this animal study compared anticonvulsant activity of quinine with that of valproate and phenytoin. Materials and Methods: Seizures were induced in adult albino Sprague/Dawley rats (n = 72) using pentylenetetrazole (PTZ) and maximum electroshock (MES) methods, comparator drugs being valproate (90 mg/kg) and phenytoin (27 mg/kg), respectively. Quinine was given in three doses (28, 35 and 42 mg/kg). Results: Higher doses of quinine (35 and 42 mg/kg) controlled PTZ seizures; efficacy was similar to valproate. MES seizures were not suppressed. Conclusion: Quinine has in-vivo anticonvulsant activity in rats in PTZ model at higher doses, but not in MES model in the doses tested.

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    Vallish, B., Sinha, S. R., Joshi, A. D., Turankar, A. V., Patel, S. B., & Mahato, R. K. (). Anticonvulsant activity of quinine in rat models of seizure in comparison with valproate and phenytoin. Journal of Young Pharmacists, 6(3), 32–36. https://doi.org/10.5530/jyp.2014.3.6