Chronic administration of ketamine induces depression in Wistar rat, but does not affect sexual function

ABSTRACT

Schizophrenia is a mental disorder that is characterized by periodic shift in positive symptoms (conceptual disorganization, delusions, hallucinations, hyperactivity, stereotypy behaviour etc.) and negative symptoms (social withdrawal, loss of function, anhedonia, decreased emotional expression, impaired concentration, and diminished social engagement).1,2 Anhedonia in experimental rats is marked by decrease in intracranial self-stimulation, consumption of sucrose solution, and sexual behavior.3 Depression is associated with different degrees of sexual dysfunction and population suffering from sexual dysfunction are frequently depressed.3,4 An acute dose of ketamine, a noncompetitive NMDA receptor antagonist is reported to relieve pain induced depression while a chronic dose of ketamine is reported to induce depression.5,1,2

KEYWORDS

Showing references and in-text citations exactly as published.

• DOI10.5530/jyp.2015.2.13Copy

RELATED ARTICLES

Matched on section and article type within this issue of JYP.

• Article · VOLUME 7, ISSUE 2Consistency between Causality Assessments Obtained With Various Scales and Their Agreement for Adverse Drug Events Reported in Pediatric PopulationDevang Ashwinkumar Rana, Sunilkumar Nagjibhai Bhadiyadara, Harsh Jayendra Shah, Supriya Deepak Malhotra, Varsha Jitendra Patel · pp. 89–95Same type: Article
• Article · VOLUME 7, ISSUE 2Evaluation of novel 1-(4-(substituted)piperazin-1-yl)- 2-(phenylamino)ethanone derivatives as Falcipain-2 inhibitorsSourabh Mundra, Radhakrishnan Mahesh · pp. 96–105Same type: Article
• Article · VOLUME 7, ISSUE 2Impact of Severity of the Disease on Cost of Illness and Quality of Life of Patients with Chronic Obstructive Pulmonary DiseaseHindu Kallaru, Vanitha Rani Nagasubramanian, Hari Prasad Balakrishnan, Kannan Gopal, Thennarasu Palani · pp. 106–112Same type: Article
• Article · VOLUME 7, ISSUE 2Inventory Management of Drugs at a Secondary Level Hospital Associated with Ballabgarh HDSS- An Experience from North IndiaShashi Kant, Partha Haldar, Arvind Singh, Ankita Kankaria · pp. 113–117Same type: Article