Combination of Ginger and Sappan Wood Extract Effect on In vivo Antithrombotic Activity Test

ABSTRACT

Introduction: Ginger (Zingiber officinale Rosc.) and sappan wood (Caesalpinia sappan L.) have been shown to inhibit platelet aggregation in vitro. Objective:This study aimed to prove the efficacy of the combination of both these plants by examining in vivo antithrombotic activity by the acute pulmonary thromboembo lism model in mice experimentally. Materials and Methods:Mice were divided into two experimental groups (bleeding time and survival rate). Acute pulmonary thromboembolism was induced after a combination of ginger and sappan wood extract pretreatment, by an intravenous injection of the mixture of a collagen and epinephrine. The paralyzed and dead mice in each group were observed and the percentage of the protective effect against thromboembolism (survival rate) was calculated. Bleeding time was observed on mice tail that had been cut. Results: The Combination of ginger and sappan wood extract at a dose of 56 mg : 14 mg/20 g/day orally, showed an antithrombotic activity due to preventing the paralysis or death (83.33%) induced by collagen-epinephrine intravenous injection. The Combination of ginger and sappan wood extract at the same dose also extending the bleeding time of mice significantly (p ≤ 0.05) compared with the normal control. Conclusion: Based on these results, a combination of ginger sappan extract has a potential effect as an antithrombotic agent.

KEYWORDS

• Antithrombotic
• Ginger
• Sappan wood
• Bleeding time
• Survival rate

Showing references and in-text citations exactly as published.

• DOI10.5530/jyp.2017.1s.12Copy

RELATED ARTICLES

Matched on section and article type within this issue of JYP.

• Article · VOLUME 9, ISSUE 1SUrinary Hydrogen Peroxide and Renal Function Parameter of Type 2 Diabetes Mellitus Patients Consuming Metformin and Metformin-SulfonylureaRani Sauriasari, Rizky Mutiara Mahani, Andisyah Putri Sekar, Azizahwati a · pp. s5–s8Original ArtcileSame type: Article
• Article · VOLUME 9, ISSUE 1SAppropriate Use of Proton Pump Inhibitor in Inpatients of Cen tral Army Gatot Soebroto HospitalMeutia Anindita, Nadia Farhanah Syafhan, Yetti Hersunaryati, Retnosari Andrajati · pp. s9–s12Original ArtcileSame type: Article
• Article · VOLUME 9, ISSUE 1SGastrointestinal Side Effects of Proton Pump Inhibitors on Inpa tients at Gatot Soebroto HospitalInas Fadhilah Hanif, Nadia Farhanah Syafhan, Yetti Hersunaryati, Retnosari Andrajati · pp. s13–s15Original ArtcileSame type: Article
• Article · VOLUME 9, ISSUE 1SThe Impact of National Formulary on Cough Medicine Prescrib ing in Three Primary Health Care in DepokAsma Zahidah, Nanda Asyura Rizkyani, Retnosari Andrajati · pp. s16–s18Original ArtcileSame type: Article