Evaluation of Adverse Drug Reactions in Tertiary Care Hospital of Kolkata, West Bengal, India

ABSTRACT

Objective:Drug is beneficial for the treatment, prevention or diagnosis of disease. However, adverse drug reactions (ADRs) associated with the use of drugs are also very common. Due to the lack of knowledge and awareness, many adverse incidents due to a drug remain unnoticed. Present study was conducted to evaluate the prevalence of adverse drug reactions in a tertiary care hospital in Kolkata, West Bengal, India. Method: Present study was an observational study based on the reports collected during July 2014 to June 2015 from different departments of a tertiary care hospital, with prior consent. The reports comprised of patients of age group ranging from 1 month to 85 years, of either sex. The causality assessment was done on the basis of “Naranjo’s Assessment Scale” and severity assessment was done in accordance with “Hartwig and Siegel scale”. Result:During the study period, among 529 prescriptions, adverse drug reactions was suspected in 287 patients. This comprised of 144 (50.17%) females and 143 (49.83%) males. According to Anatomical Therapeutic Chemical (ATC) Classification System, the drug mostly associated with adverse drug reac tions was anti-infective agents (63.07%). The causality assessment according to Naranjo Scale showed 5% ADRs have definite, 40% probable and 55% possible correlation.Conclusion: In order to ensure a better treatment regimen and improve patients’ compliance, it is essential to reduce and prevent adverse drug reaction. Implementation of pharmacovigilance programs in the hospitals is thus essential to enhance the awareness regarding early detection, reporting, management and further prevention of Adverse Drug Reactions.

KEYWORDS

• Adverse Drug Reaction (ADR)
• Pharmacovigilance
• Tertiary care hospital
• Anti-infective agents
• Causality assessment

Showing references and in-text citations exactly as published.

• DOI10.5530/jyp.2017.9.62Copy

RELATED ARTICLES

Matched on section and article type within this issue of JYP.

• Article · VOLUME 9, ISSUE 3Analyses of Deposited and Granted Patents at Federal University of Ceara in BrazilLídia Audrey Rocha Valadas, Lídia Rodrigues Queiroz, Mary Anne Medeiros Bandeira, Rosueti Diógenes de Oliveira Filho, Érika Sabóia Guerra Diógenes, Ana Cristina de Mello Fiallos, Nicole de Mello Fiallos, Rávilla Alves da Silva, José Ronildo Lins do Carmo Filho, Camila Costa Dias, Emerson Dias Ponte, Carlos Eduardo Lima Fernandes, Allana Bezerra Capistrano, Paulo Arthur Mendonça Bruno, João Hildo de Carvalho Furtado Júnior · pp. 307–310Original ArtcileSame type: Article
• Article · VOLUME 9, ISSUE 3Toxicological Pattern of Poisoning in Urban Hospitals of Western IndiaRaut Asawari, Pawar Atmaram, Kakane Bhagwan, Dave Priti, Shaj Kavya, Gulam Ali Jabeen · pp. 315–320Original ArtcileSame type: Article
• Article · VOLUME 9, ISSUE 3Antidiabetic, Antihyperlipidemic, Antioxidant Property of Cordia obliqua on Streptozotocin Induced Diabetic RatsPrakash Ramakrishnan, Dhivya Ramadoss, Priyadarshini Muthulingam, Ramya Nedunchezhian, Karthick Krishnamoorthy · pp. 321–326Original ArtcileSame type: Article
• Article · VOLUME 9, ISSUE 3Cemented Versus Cementless Primary Hip Replacement: Assessment of Leg Length InequalityWisam A Yassin, Abdul Rakib Al-Mirah, Abdullah Ali Almoaish, Myat Moe Thwe Aung, Atif AB, Tarik Ibrahem Ali, Naghem Farouk Abed · pp. 327–331Original ArtcileSame type: Article